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PGS has been the most effective method for embryo selection in IVF cycles. Euploidy rates decrease significantly with advancing maternal age (AMA). The dosage of gonadotropins also may be increased to recruit an adequate number of follicles in AMA women, minimal Stimulation Protocol (MSP) with the new combination of human menopausal gonadotrophin (hMG) and clomiphene citrate (CC) for controlled ovarian hyperstimulation is defined for poor ovarian response women. The aim of this study is to show minimal stimulation protocol affect euploidy and pregnancy rates in preimplatation genetic screening (PGS) cycles with single embryo transfer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 100 patients with minimal | In advancing maternal age (AMA) women, minimal stimulation protocol (MSP) with the new combination of human menopausal gonadotrophin (hMG) and clomiphene citrate (CC) were performed for controlled ovarian hyperstimulation is defined for poor ovarian response women. |
| |
| 100 patients with recombinant FSH antagonist protocol | In advancing maternal age (AMA) women, flexible antagonist protocol with recombinant FSH were performed for controlled ovarian hyperstimulation is defined for poor ovarian response women. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| protocol | Genetic | ovarian stimulation protocols on euploid rates were compared. |
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| Measure | Description | Time Frame |
|---|---|---|
| euploid rates | the effects of different stimulation protocols on euploid rates | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| pregnancy rates | the effects of different stimulation protocols on pregnancy rates | 3 months |
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Inclusion Criteria: Advanced maternal aged -
Exclusion Criteria: Severe male factor, endometriosis, and absolute tubal factor were excluded in this study.
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more than 38 years old
200 advanced maternal aged women
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gokalp Oner | Not yet recruiting | Kayseri | Gevher Nesibe | 38039 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D002985 | Clinical Protocols |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D016020 | Epidemiologic Study Characteristics |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
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embryo
| Gokalp Oner | Recruiting | Kayseri | Gevher Nesibe | 38039 | Turkey (Türkiye) |
|
| D017530 | Health Care Quality, Access, and Evaluation |