Targeting the Carotid Bodies to Reduce Disease Risk Along the Diabetes Continuum

Targeting the Carotid Bodies to Reduce Disease Risk Along the Diabetes Continuum

Our overall goal is to advance our understanding of the contribution of the carotid body chemoreceptors in glucose regulation and the development of type 2 diabetes.

Inclusion Criteria:

• healthy,
• type 2 diabetes
• BMI 18-40 kg/m2,
• non-pregnant,
• non-breastfeeding,
• non-nicotine users.

Exclusion Criteria:

• cardiovascular disease including myocardial infarction, heart failure, coronary artery disease, stroke;
• renal or hepatic diseases;
• active cancer;
• autoimmune diseases;
• immunosuppressant therapy;
• excessive alcohol consumption (>14 drinks/week);
• current nicotine use;
• foot ulcers;
• diabetic neuropathy;
• medication directly influencing sympathetic nervous system activity