Exercise in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection Study

Exercise Training and Functional, Cognitive, and Emotional Well-being in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection (PASC): a Randomized Controlled Trial

To examine the efficacy of an 8-week exercise training program on functional, cognitive, and emotional health outcomes compared to a no treatment control condition in adults with PASC.

Conduct a randomized control trial with a wait-list control to examine the efficacy of an 8-week exercise training program on functional, cognitive, and emotional health outcomes compared to a no treatment control condition in adults with PASC.

Examine participant compliance (in-person attendance, online engagement) with the 8-week exercise training program including in-person exercise sessions, cognitive performance training, and virtual exercise sessions delivered via a mobile application.

To determine if compliance with the 8-week exercise training program is associated with improvement in functional, cognitive, and emotional health outcomes.

Determine if there is a maintenance effect for individuals randomized into the 8-week exercise training program by comparing their outcomes at the end of the 8-week training exercise program to their outcomes at the end of their trial participation (16 weeks).

Inclusion Criteria:

• 18-65 years of age
• Self-reported history of COVID-19 diagnosis
• Self-reported ongoing symptoms of PASC >4 weeks after initial infection

Exclusion Criteria:

• Neuromotor, musculoskeletal, or rheumatoid disorders that are exacerbated by exercise or conditions preventing cooperation
• COVID-19 infection occurring > 6 months prior to screening date
• Contraindications to Symptom-limited Maximal Exercise Testing
• Individuals without access to a device with iOS (apple devices such as iPhone, iPad, MacBook, etc.)
• Patient-reported diagnosis of severe arterial hypertension
• Patient reported metabolic disease
• Patient reported uncontrolled asthma
• Inmates
• Pregnancy
• Patient reported supplemental O2 use
• Presence of beards
• Patient reported diagnosis of claustrophobia
• Non-English speaking