Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LKD syndrome | liver and kidney deficiency syndrome |
| |
| PBS syndrome | phlegm and blood stasis syndrome |
| |
| NC group | Normal Control group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cross-sectional study without intervention | Other | cross-sectional study without intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| the differences of metabonomics | The differences of metabonomics in blood, urine and tongue coating will be detected by metabonomics in LKD group, PBS group and NC group. | 3 years |
| the differences of metabonomics in the cell models of disease-TCM syndrome | The differences of metabonomics in the cell models of disease-TCM syndrome will be detected by metabonomics. | 3 years |
| the differences of proteomics in the cell models of disease-TCM syndrome | The differences of proteomics in the cell models of disease-TCM syndrome will be detected by proteomics. | 3 years |
| the differences of proteomics | The differences of proteomics in blood, urine and tongue coating will be detected by proteomics in LKD group, PBS group and NC group. | 3 years |
| the differences of transcriptomics | The differences of transcriptomics in blood, urine and tongue coating will be detected by transcriptomics in LKD group, PBS group and NC group. | 3 years |
| the differences of transcriptomics in the cell models of disease-TCM syndrome | The differences of transcriptomics in the cell models of disease-TCM syndrome will be detected by transcriptomics. | 3 years |
| the related indexes of TGF- β/ Smad signaling pathway and inflammatory response |
Not provided
Not provided
Inclusion Criteria:
Inclusion criteria of liver and kidney deficiency syndrome and phlegm and blood stasis syndrome in knee osteoarthritis
Inclusion criteria of normal control group
Exclusion Criteria:
Not provided
Not provided
Among the outpatients and inpatients in Dongzhimen Hospital of Beijing University of traditional Chinese medicine from December 2021 to August 2024, 150 cases of liver and kidney deficiency syndrome and 300 cases of phlegm and blood stasis syndrome were taken respectively. All patients met the diagnosis of knee osteoarthritis and met the inclusion criteria. Another 40 cases of normal control group were taken.
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dongzhimen Hospital | Recruiting | Beijing | Beijing Municipality | 100700 | China |
Not provided
Not provided
Not provided
Not provided
Histological and pathological examination is used to detect the related indexes of TGF- β/ Smad signaling pathway and inflammatory response.
| 3 years |
| The clinical TCM scores of LKD | The minimum value is 0 and maximum value is 38, and higher scores mean a worse outcome. | 3 years |
| The clinical TCM scores of PBS | The minimum value is 0 and maximum value is 41, and higher scores mean a worse outcome. | 3 years |
| The grading scores of Kellgren Lawrence (K-L) | The minimum value is 0 and maximum value is 4, and higher scores mean a worse outcome. | 3 years |
| The grading scores of Yulish | The minimum value is 0 and maximum value is 4, and higher scores mean a worse outcome. | 3 years |
| Clinical data | Collect clinical data and formulate a unified questionnaire, including the name, age, gender, outpatient / inpatient number, past history, current medical history, imaging images and other relevant data of patients with knee osteoarthritis. | 3 years |
| Concentration of BLC (CXCL13) | Concentration of BLC (CXCL13) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of BLC (CXCL13) in the cell models of disease-TCM syndrome | Concentration of BLC (CXCL13) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of Eotaxin-1 (CCL11) | Concentration of Eotaxin-1 (CCL11) will be detected by ELISA will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of Eotaxin-1 (CCL11) in the cell models of disease-TCM syndrome | Concentration of Eotaxin-1 (CCL11) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of Eotaxin-2 (MPIF-2/CCL24) | Concentration of Eotaxin-2 (MPIF-2/CCL24) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of Eotaxin-2 (MPIF-2/CCL24) in the cell models of disease-TCM syndrome | Concentration of Eotaxin-2 (MPIF-2/CCL24) will be detected by ELISA in the cell models of disease-TCM. | 3 years |
| Concentration of GCSF | Concentration of GCSF will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of GCSF in the cell models of disease-TCM syndrome | Concentration of GCSF will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of GM-CSF | Concentration of GM-CSF will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of GM-CSF in the cell models of disease-TCM syndrome | Concentration of GM-CSF will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of I-309 (TCA-3/CCL1) | Concentration of I-309 (TCA-3/CCL1) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of I-309 (TCA-3/CCL1) in the cell models of disease-TCM syndrome | Concentration of I-309 (TCA-3/CCL1) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of ICAM-1(CD54) | Concentration of ICAM-1(CD54) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of ICAM-1(CD54) in the cell models of disease-TCM syndrome | Concentration of ICAM-1(CD54) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IFN-gamma | Concentration of IFN-gamma will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IFN-gamma in the cell models of disease-TCM syndrome | Concentration of IFN-gamma will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-1 alpha (IL-1 F1) | Concentration of IL-1 alpha (IL-1 F1) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-1 alpha (IL-1 F1) in the cell models of disease-TCM syndrome | Concentration of IL-1 alpha (IL-1 F1) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-1 beta (IL-1 F2) | Concentration of IL-1 beta (IL-1 F2) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-1 beta (IL-1 F2) in the cell models of disease-TCM syndrome | Concentration of IL-1 beta (IL-1 F2) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-1 ra (IL-1 F3) | Concentration of IL-1 ra (IL-1 F3) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-1 ra (IL-1 F3) in the cell models of disease-TCM syndrome | Concentration of IL-1 ra (IL-1 F3) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-2 | Concentration of IL-2 will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-2 in the cell models of disease-TCM syndrome | Concentration of IL-2 will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-4 | Concentration of IL-4 will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-4 in the cell models of disease-TCM syndrome | Concentration of IL-4 will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-5 | Concentration of IL-5 will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-5 in the cell models of disease-TCM syndrome | Concentration of IL-5 will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-6 | Concentration of IL-6 will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-6 in the cell models of disease-TCM syndrome | Concentration of IL-6 will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-6R | Concentration of IL-6R will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-6R in the cell models of disease-TCM syndrome | Concentration of IL-6R will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-7 | Concentration of IL-7 will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-7 in the cell models of disease-TCM syndrome | Concentration of IL-7 will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-8(CXCL8) | Concentration of IL-8(CXCL8) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-8(CXCL8) in the cell models of disease-TCM syndrome | Concentration of IL-8(CXCL8) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-10 | Concentration of IL-10 will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-10 in the cell models of disease-TCM syndrome | Concentration of IL-10 will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-11 | Concentration of IL-11 will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-11 in the cell models of disease-TCM syndrome | Concentration of IL-11 will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-12 p40 | Concentration of IL-12 p40 will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-12 p40 in the cell models of disease-TCM syndrome | Concentration of IL-12 p40 will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-12 p70 | Concentration of IL-12 p70 will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-12 p70 in the cell models of disease-TCM syndrome | Concentration of IL-12 p70 will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-13 | Concentration of IL-13 will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-13 in the cell models of disease-TCM syndrome | Concentration of IL-13 will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-15 | Concentration of IL-15 will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-15 in the cell models of disease-TCM syndrome | Concentration of IL-15 will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-16 | Concentration of IL-16 will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-16 in the cell models of disease-TCM syndrome | Concentration of IL-16 will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of IL-17A | Concentration of IL-17A will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of IL-17A in the cell models of disease-TCM syndrome | Concentration of IL-17A will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of MCP-1 (CCL2) | Concentration of MCP-1 (CCL2) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of MCP-1 (CCL2) in the cell models of disease-TCM syndrome | Concentration of MCP-1 (CCL2) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of M-CSF | Concentration of M-CSF will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of M-CSF in the cell models of disease-TCM syndrome | Concentration of M-CSF will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of MIG (CXCL9) | Concentration of MIG (CXCL9) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of MIG (CXCL9) in the cell models of disease-TCM syndrome | Concentration of MIG (CXCL9) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of MIP-1 | Concentration of MIP-1 will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of MIP-1 in the cell models of disease-TCM syndrome | Concentration of MIP-1 will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of alpha (CCL3) in the cell models of disease-TCM syndrome | Concentration of alpha (CCL3) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of alpha (CCL3) | Concentration of alpha (CCL3) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of MIP-1 beta (CCL4) | Concentration of MIP-1 beta (CCL4) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of MIP-1 beta (CCL4) in the cell models of disease-TCM syndrome | Concentration of MIP-1 beta (CCL4) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of MIP-1 delta (CCL15) | Concentration of MIP-1 delta (CCL15) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of MIP-1 delta (CCL15) in the cell models of disease-TCM syndrome | Concentration of MIP-1 delta (CCL15) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of PDGF-BB | Concentration of PDGF-BB will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of PDGF-BB in the cell models of disease-TCM syndrome | Concentration of PDGF-BB will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of RANTES (CCL5) | Concentration of RANTES (CCL5) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of RANTES (CCL5) in the cell models of disease-TCM syndrome | Concentration of RANTES (CCL5) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of TIMP-1 | Concentration of TIMP-1 will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of TIMP-1 in the cell models of disease-TCM syndrome | Concentration of TIMP-1 will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of TIMP-2 | Concentration of TIMP-2 will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of TIMP-2 in the cell models of disease-TCM syndrome | Concentration of TIMP-2 will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of TNF alpha | Concentration of TNF alpha will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of TNF alpha in the cell models of disease-TCM syndrome | Concentration of TNF alpha will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of TNF beta (TNFSF1B) | Concentration of TNF beta (TNFSF1B) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of TNF beta (TNFSF1B) in the cell models of disease-TCM syndrome | Concentration of TNF beta (TNFSF1B) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of TNF RI (TNFRSF1A) | Concentration of TNF RI (TNFRSF1A) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of TNF RI (TNFRSF1A) in the cell models of disease-TCM syndrome | Concentration of TNF RI (TNFRSF1A) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of TNF RII(TNFRSF1B) | Concentration of TNF RII(TNFRSF1B) will be detected by ELISA in LKD group, PBS group and NC group. | 3 years |
| Concentration of TNF RII(TNFRSF1B) in the cell models of disease-TCM syndrome | Concentration of TNF RII(TNFRSF1B) will be detected by ELISA in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of Signaling pathway indicator | Concentration of Signaling pathway indicator will be detected by ELISA, metabonomics, proteomics, transcriptomics in LKD group, PBS group and NC group. | 3 years |
| Concentration of Signaling pathway indicator in the cell models of disease-TCM syndrome | Concentration of Signaling pathway indicator will be detected by ELISA, metabonomics, proteomics, transcriptomics in the cell models of disease-TCM syndrome. | 3 years |
| Concentration of Routine Blood Examination （Concentration of WBC, LYMPH%, MONO, NEUT%, LYMPH, MONO%, NEUT, BASO%, BASO, MCH, MCHC,ROW-CV, MPV, PLT, PDW, EO%, P-LCR, RBC, Hb, HCT） | LKD group, PBS group and NC group's Routine Blood Examination will be detect by automated hematology analyzer. | 3 years |
| Concentration of Blood Biochemistry (Concentration of TC, TG, HDL-C, LDL-C, Urea, Cr, UA, GLu, ALT, AST, TP, ALB, ALP, GGT, TBIL, DBIL, Mg, K, Na, Cl, Ca, P, Fe, CO2) | LKD group, PBS group and NC group's Blood Biochemistry will be detect by automatic biochemical analyzer. | 3 years |
| Concentration of Routine Urine Examination (Concentration of LEU, NIT, PRO, GLU-U, KET, URO, BIL, PH-U, SG, BLU) | LKD group, PBS group and NC group's Routine Urine Examination will be detect by Urine analyzer. | 3 years |
| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| D013577 | Syndrome |
| D004194 | Disease |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
| ID | Term |
|---|---|
| D003430 | Cross-Sectional Studies |
| D008722 | Methods |
| ID | Term |
|---|---|
| D016021 | Epidemiologic Studies |
| D016020 | Epidemiologic Study Characteristics |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
Not provided
Not provided