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Dysfunctional breathing might participate to dyspnoea in long COVID-19. This study investigate the prognosis of patients diagnosed with dysfunctional breathing after SARS-CoV-2 infection in our center.
Dysfunctional breathing (DB) with or without hyperventilation syndrome (HVS) as diagnosed using cardiopulmonary exercise test (CPET) was recently demonstrated as an important physiopathological mechanism of persistent dyspnoea in long COVID patients [1]. DB is characterized by specific ventilation pattern on CPET accompanied by respiratory discomfort and/or dyspnea at exercise [2]. Most patients with DB will have undergone some sort a specific physiotherapy retraining [3]. However the prognostic and the predictors of persistence/resolution of DB after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are unknown.
The aim of the study is to determine the prognostic of patients diagnosed with DB after SARS-CoV-2 infection, as well as prognosis factors and predictors of persistence/resolution of DB during a prospective follow up visit.
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| Measure | Description | Time Frame |
|---|---|---|
| Persistence/resolution of dysfunctional breathing at follow-up visit | defined by persistence/resolution of dyspnea, as compared with patient's baseline (equivalent level of dyspnea as before COVID-19). | 6 to 9 monts from diagnosis |
| Measure | Description | Time Frame |
|---|---|---|
| Change in ventilatory patterns (tidal volume [VT], breathing frequency [BF] at isowork as compared with baseline | 6 to 9 monts from diagnosis | |
| Dispersion of VT and BF during the CPET | 6 to 9 monts from diagnosis |
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Inclusion Criteria:
Exclusion Criteria:
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- Patients of 14 years or more diagnosed with DB after COVID-19 using a combined approach of symptoms and CPET in the Hospitals of Sion, of Martigny or Rennaz
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pierre-Olivier v Bridevaux | Contact | +41792079069 | pierre-olivier.bridevaux@hopitalvs.ch | |
| Léon Genecand | Contact | +41799372687 | leon.genecand@hcuge.ch |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre hospitalier du valais romand | Recruiting | Martigny-Ville | Switzerland |
Data upon reasonable requests
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| Change in ETCO2 and PaCO2 | 6 to 9 monts from diagnosis |
| Qualitative changes (increase/decrease/no change of DB pattern of CPET) | 6 to 9 monts from diagnosis |
| Score HADS changes | 6 to 9 monts from diagnosis |
| Score SF-36 changes | 6 to 9 monts from diagnosis |
| Specific symptom scale changes | 6 to 9 monts from diagnosis |
| Specific work capacity changes questions | 6 to 9 monts from diagnosis |
| Post-COVID Functional Status (PCFS) changes | 6 to 9 monts from diagnosis |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |