Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Cytokines, such as IL-6 and IL-8 can be used as markers of acute infections, including acute gastroenteritis. This study aims to evaluate serum levels of interleukins 6 and 8 in children with acute gastroenteritis.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cases | Children with acute diarrhea |
| |
| Control | Healthy control children |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Evaluation of serum levels of IL-6 and IL-8 | Diagnostic Test | Evaluation of serum levels of IL-6 and IL-8 by Luminex Assay (multiplexed ELISA kits) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Serum level of Interleukin 6 | Difference in serum level of interleukin 6 between cases and control groups | Within the first 3 days of acute diarrhea |
| Serum level of Interleukin 8 | Difference in serum level of interleukin 8 between cases and control groups | Within the first 3 days of acute diarrhea |
Not provided
Not provided
Group 1: Cases (Children with acute diarrhea)
Inclusion Criteria:
Exclusion Criteria:
Group 2: Controls (Healthy control children)
Inclusion Criteria:
• Healthy children aged 6 months to 5 years.
Exclusion Criteria:
Not provided
Not provided
Children presented to the Pediatric Department and Outpatient Clinic at Sohag University Hospital
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| John s shaker, MBBCH | Contact | 012057258026 | johnshaker@med.sohag.edu.eg | |
| Ashraf M Radwan, MD, PhD | Contact |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag University Hospital | Recruiting | Sohag | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30945960 | Background | Muhsen K, Kassem E, Rubenstein U, Goren S, Ephros M, Shulman LM, Cohen D. No evidence of an increase in the incidence of norovirus gastroenteritis hospitalizations in young children after the introduction of universal rotavirus immunization in Israel. Hum Vaccin Immunother. 2019;15(6):1284-1293. doi: 10.1080/21645515.2019.1599522. Epub 2019 May 3. | |
| 23899552 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Type | Date | Date Unknown |
|---|---|---|
| Release | Jan 16, 2023 | |
| Reset | Nov 3, 2023 |
Not provided
Not provided
| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jan 16, 2023 | Nov 3, 2023 |
Not provided
Not provided
Not provided
| Chen SM, Lin CP, Tsai JD, Chao YH, Sheu JN. The significance of serum and fecal levels of interleukin-6 and interleukin-8 in hospitalized children with acute rotavirus and norovirus gastroenteritis. Pediatr Neonatol. 2014 Apr;55(2):120-6. doi: 10.1016/j.pedneo.2013.05.008. Epub 2013 Jul 27. |
| 29371270 | Background | Hamiel U, Bahat H, Kozer E, Hamiel Y, Ziv-Baran T, Goldman M. Diagnostic markers of acute infections in infants aged 1 week to 3 months: a retrospective cohort study. BMJ Open. 2018 Jan 24;8(1):e018092. doi: 10.1136/bmjopen-2017-018092. |