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| Name | Class |
|---|---|
| Rennes University Hospital | OTHER |
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Chronic Obstructive Pulmonary Disease (COPD) is a common chronic respiratory disease, causing disabling respiratory symptoms and impairing patients' quality of life. Currently one of the leading causes of death worldwide, COPD is a major socio-economic concern. It is also accompanied by extremely frequent extra-respiratory manifestations (or co-morbidities). Among these secondary manifestations, the equilibrium of these patients is subject to modifications: thus, numerous studies have shown that the equilibrium of COPD patients was altered compared to healthy age-matched subjects. This alteration is associated with a greater functional limitation and a higher risk of falling. Although this impairment has been demonstrated clinically, the balance of these patients has never been analysed using quantified movement analysis tools during tasks similar to those performed in daily life. Moreover, the underlying mechanisms remain unknown and the possible associations with several clinical factors of interest (pain, dyspnea, muscle function...) have not yet been assessed. The hypotheses of this project are that (1) the postural control of COPD patients is altered compared to healthy subjects during tasks of daily living and these changes can be characterised. (2) Several clinical factors are associated with these changes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COPD patients |
| ||
| Healthy controls |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| quantified analysis of postural control during activities of daily living | Other | functional tests that reproduce tasks of daily living (timed up and go test with and without dual cognitive task, modified Glittre ADL test) |
| Measure | Description | Time Frame |
|---|---|---|
| Margins of stability | Postural control parameter related to the centre of mass (CoM) and the base of support of the participant, assessed during the functional tests | Clinical assessment at baseline |
| Margins of stability variability | Coefficient of variation of a postural control parameter related to the centre of mass (CoM) and the base of support of the participant, assessed during the functional tests | Clinical assessment at baseline |
| Center of Mass velocity | Parameter of participant's Centre of Mass (CoM) during the functional tests | Clinical assessment at baseline |
| Center of mass displacement | Parameter of participant's Centre of Mass (CoM) during the functional tests | Clinical assessment at baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Evolution of articular angulations | Articular angulations assessed at the ankle, knee, hip, spine and thoracic level during the functional tests | Clinical assessment at baseline |
| Centre of pressure (CoP) Area |
| Measure | Description | Time Frame |
|---|---|---|
| Dyspnea assessment scale | assessed by the modified Borg Scale which is a 0 to 10 scale (0 representing no dyspnea, 10 representing the worst imaginable dyspnea). Dyspnea is assessed before, during and after the functional tests | Clinical assessment at baseline |
| Heart rate |
Inclusion Criteria:
Exclusion Criteria:
the presence of long-term or exercise-based oxygen therapy,
the presence of a medically diagnosed pathology causing manifest disorders of balance,
the inability to walk 150 m without stopping and to climb or descend stairs,
a history of pneumonectomy or lobectomy within the last six months,
the existence of an acute respiratory exacerbation within the last two months,
the presence of obvious cognitive impairment that impairs comprehension of instructions,
body mass index less than 21 or more than 35 kg/m².
Person referred to in articles L. 1121-5 to L. 1121-8 and L. 1121-12 of the public health code:
Person under psychiatric care
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COPD patients that realize their medical follow-up at University Hospital of Rennes
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Romain Pichon, MSc | Contact | 0667774267 | r.pichon@ifpek.org | |
| Armel Cretual, PhD | Contact | armel.cretual@univ-rennes2.fr |
| Name | Affiliation | Role |
|---|---|---|
| Graziella Brinchault, MD | University Hospital of Rennes | Principal Investigator |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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Parameter of participant's Centre of Pressure (CoP) during the sit to stand and stand to sit tasks of the Glittre-ADL test
| Clinical assessment at baseline |
| Centre of pressure (CoP) velocity | Parameter of participant's Centre of Pressure (CoP) during the sit to stand and stand to sit tasks of the Glittre-ADL test | Clinical assessment at baseline |
| Centre of pressure (CoP) variability | Coefficient of variation of participant's Centre of Pressure (CoP) during the sit to stand and stand to sit tasks of the Glittre-ADL test | Clinical assessment at baseline |
| Gait Cadence | spatio-temporal parameter of gait assessed during the walking part of the Glittre-ADL test | Clinical assessment at baseline |
| Gait velocity | spatio-temporal parameter of gait assessed during the walking part of the Glittre-ADL test | Clinical assessment at baseline |
| Gait phases duration | spatio-temporal parameter of gait assessed during the walking part of the Glittre-ADL test | Clinical assessment at baseline |
| Step width | spatio-temporal parameter of gait assessed during the walking part of the Glittre-ADL test | Clinical assessment at baseline |
| Step length | spatio-temporal parameter of gait assessed during the walking part of the Glittre-ADL test | Clinical assessment at baseline |
| Completion time of the Modified Glittre ADL | Time to complete the modified Glittre-ADL test | Clinical assessment at baseline |
| Completion time of the timed up and go test | Time to complete the timed up and go test test | Clinical assessment at baseline |
assessed before, during and after functional tests |
| Clinical assessment at baseline |
| Leg discomfort scale | assessed on a 0 to 10 scale (0 representing no discomfort, 10 representing the worst imaginable discomfort).Leg discomfort is assessed before, during and after the functional tests | Clinical assessment at baseline |
| Visual analog scale for pain | Pain is assessed by a visual analog scale which is a 100mm long horizontal line with verbal descriptors at each end to express the extremes of the feeling (Here no pain and the worst imaginable pain) | Clinical assessment at baseline |
| Pain Drawing scale | participants are invited to identify on a body chart the location of experienced pain. | Clinical assessment at baseline |
| Multi-dimensional dyspnea profile (MDP) | Dyspnea assessment tool which investigates sensory and affective dimensions of dyspnea | Clinical assessment at baseline |
| London chest activity of daily living questionnaire (LCADL) | Dyspnea assessment tool which investigates the impact of dyspnea on 15 activities of daily living. A score from 0 to 5 is given for each activity, 5 representing an higher impact of dyspnea on the activity. | Clinical assessment at baseline |
| Modified Medical Research Council Scale (MMRC) | Dyspnea assessment tool which investigates impact of dyspnea in participants life. This is a 0 to 4 scale with descriptors associated to each number. 4 representing the most severe impact of dyspnea. | Clinical assessment at baseline |
| Charlson Index | Comorbidities assessment tool which list 19 potential comorbidities associated with a weighted score. The points are attributed when the comorbidity is present. A total score is then calculated. An higher score indicates an higher severity. | Clinical assessment at baseline |
| Body composition | Determination of fat free mass and fat mass by bioelectrical impedance analysis. | Clinical assessment at baseline |
| Maximal inspiratory pressure | inspiratory muscles strength assessment | Clinical assessment at baseline |
| Falls Efficacy Scale - International | Fear of falling assessment tool which investigates fear of falling in 16 different activities. Each activity is scored from 0 to 4 (4 representing an higher fear of falling in this activity). The total score range from 16 to 64 (an higher score indicating a most severe fear of falling) | Clinical assessment at baseline |
| Number of anterior falls | assessment of fall occurence in the last 12 months | Clinical assessment at baseline |
| General Practioner assessment of Cognition (GP-COG) | assessment of cognitive function. GP-COG gives a score from 0 to 9 (9 indicating a better cognitive function) | Clinical assessment at baseline |
| International Physical Activity Questionnaire (IPAQ short-form) | assessment of daily physical activity and sedentarity | Clinical assessment at baseline |
| COPD assessment test (CAT) | quality of life assessment tool | Clinical assessment at baseline |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |