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The purpose of this study is to investigate whether the use of a preoperative antibiotic bowel regimen is associated with a reduced risk of deep organ/space surgical site infection in gynecologic oncology surgery.
This is a retrospective chart review study. Patients who underwent scheduled intra-abdominal surgery with a WellSpan gynecologic oncologist will be identified and their chart reviewed for demographic data of age, race, BMI, comorbidities, and type of surgery. Those patients who had a deep organ/space surgical site infection within 30 days postoperatively will be identified. The numbers of these infections before and after August 2020, at which time all patients moving forwards were prescribed antibiotic bowel preparation, will then be statistically analyzed and compared to see if the institution of the antibiotic bowel preparation was associated with a reduction in surgical site infection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No Antibiotic Bowel Prep | Patients who did not receive a preoperative antibiotic bowel preparation |
| |
| Antibiotic Bowel Prep | Patients who did receive a preoperative antibiotic bowel preparation |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diagnosed with Surgical Site Infection | Other | As an observational study, this notates patients who were diagnosed with a deep organ/space surgical site infection within 30 days of surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Surgical Site Infection Rates Associated with Antibiotic Bowel Prep | Rate of surgical site infection rate as associated with or without use of antibiotic bowel preparation | 2019-2021 |
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Inclusion Criteria:
- Underwent scheduled intra-abdominal surgery with a WellSpan gynecologic oncologist
Exclusion Criteria:
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Patients who had intra-abdominal surgery by a WellSpan gynecologic oncologist from 2019-2021 as identified by review of the surgical schedule.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| WellSpan | York | Pennsylvania | 17403 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19160191 | Background | Nelson RL, Glenny AM, Song F. Antimicrobial prophylaxis for colorectal surgery. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD001181. doi: 10.1002/14651858.CD001181.pub3. | |
| 25607761 | Background | Morris MS, Graham LA, Chu DI, Cannon JA, Hawn MT. Oral Antibiotic Bowel Preparation Significantly Reduces Surgical Site Infection Rates and Readmission Rates in Elective Colorectal Surgery. Ann Surg. 2015 Jun;261(6):1034-40. doi: 10.1097/SLA.0000000000001125. |
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| ID | Term |
|---|---|
| D013530 | Surgical Wound Infection |
| ID | Term |
|---|---|
| D014946 | Wound Infection |
| D007239 | Infections |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
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| 32112733 | Background | Kalogera E, Van Houten HK, Sangaralingham LR, Borah BJ, Dowdy SC. Use of bowel preparation does not reduce postoperative infectious morbidity following minimally invasive or open hysterectomies. Am J Obstet Gynecol. 2020 Aug;223(2):231.e1-231.e12. doi: 10.1016/j.ajog.2020.02.035. Epub 2020 Feb 26. |
| 4743867 | Background | Nichols RL, Broido P, Condon RE, Gorbach SL, Nyhus LM. Effect of preoperative neomycin-erythromycin intestinal preparation on the incidence of infectious complications following colon surgery. Ann Surg. 1973 Oct;178(4):453-62. doi: 10.1097/00000658-197310000-00008. No abstract available. |
| 39376031 | Derived | Kennedy K, Gaertner-Otto J, Lim E. Reduction in deep organ-space infection in gynecologic oncology surgery with use of oral antibiotic bowel preparation: a retrospective cohort analysis. J Osteopath Med. 2024 Oct 9;125(5):269-276. doi: 10.1515/jom-2024-0099. eCollection 2025 May 1. |
| D013568 |
| Pathological Conditions, Signs and Symptoms |