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To investigate the value of CTCs and ctDNA in the diagnosis of metastasis in ascites/peritoneal flushing fluid and blood; To investigate the influence of laparoscopic CO2 pneumoperitoneum establishment on peritoneal and hematogenous metastasis of advanced gastric cancer; To explore the influence of the number and type of CTCs and ctDNA on metastasis and prognosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Laparotomy group | Patients who undergo radical laparotomy for gastric cancer. |
| |
| Laparoscopy group | Patients who undergo laparoscope-assisted radical gastrectomy for gastric cancer. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CTC test | Diagnostic Test | Circulating tumor cells test of ascites and blood for patients with gastric cancer. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Quantity of CTCs | To count the circulating tumor cells in ascites and blood. | 1 day |
| Classification of CTCs | To classify the circulating tumor cells in ascites and blood. | 1 day |
| Expression of ctDNA | To assess the expression of circulating tumor DNA in ascites and blood, including YAP1, LAMC1 and DDIT4. | 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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Borrmann III and Borrmann IV patients will be selected from Department of Oncology in hospitals. All patients will undergo either laparotomy or laparoscopic surgery.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kai Li, MD | Contact | 8613998245233 | cmu1h_likai@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Kai Li, MD | First Hospital of China Medical University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| First Hospital of Jinzhou Medical University | Recruiting | Jinzhou | Liaoning | 121012 | China |
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| ID | Term |
|---|---|
| D013274 | Stomach Neoplasms |
| D009362 | Neoplasm Metastasis |
| D004194 | Disease |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ctDNA test | Diagnostic Test | Circulating tumor DNA test of ascites and blood for patients with gastric cancer. |
|
| The First Affiliated Hospital of China Medical University | Active, not recruiting | Shenyang | Liaoning | 110000 | China |
| D004066 |
| Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D013272 | Stomach Diseases |
| D009385 | Neoplastic Processes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |