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This study aims to determine the independent and combined effects of prebiotic fiber supplementation and exercise on the gut microbiome and human health.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise + Prebiotic | Experimental | The Exercise + Prebiotic intervention group will consume 10 g/d of fructo-oligosaccharides (FOS). Additionally, they will perform 6 wk. of supervised progressive multi-component exercise training consisting of moderate to vigorous aerobic and strength-based exercises (3x/wk). |
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| Exercise + Placebo | Placebo Comparator | The Exercise + Placebo group will consume 10 g/d of a placebo (maltodextrin) powder every day. Additionally, they will perform 6 wk. of supervised progressive multi-component exercise training consisting of moderate to vigorous aerobic and strength-based exercises (3x/wk). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fructooligosaccharides (FOS) | Dietary Supplement | FOS (NUTRAFLORA® P-95, Ingredion) supplements (10g/day) will be consumed daily mixed with water. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in gastrointestinal microbiota composition | Determine the impact of daily consumption of prebiotic combined with regular exercise on the gastrointestinal microbiota compared to control by sequencing the V4 region of the 16S rRNA gene in fecal samples. | Baseline & 6-week mark |
| Changes in gastrointestinal microbial-derived metabolite concentrations | Determine the impact of daily consumption of prebiotic combined with regular exercise on the concentration of short-chain fatty acids compared to control. | Baseline & 6-week mark |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in fasting glucose | Determine the impact of daily consumption of prebiotic combined with regular exercise on fasting glucose compared to control. | Baseline & 6-week mark |
| Changes in fasting insulin |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in lipid profiles | Determine the impact of daily consumption of prebiotic combined with regular exercise on fasting lipid profiles including cholesterol and triglycerides compared to control. | Baseline & 6-week mark |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mikaela Webb, BS, RD | Contact | (217) 300-9577 | mwebb24@illinois.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Illinois at Urbana-Champaign | Recruiting | Urbana | Illinois | 61801 | United States |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| ID | Term |
|---|---|
| C116580 | fructooligosaccharide |
| D015444 | Exercise |
| C008315 | maltodextrin |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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The study is a randomized, controlled trial with a 6-week intervention period with two groups: 1) Exercise + Prebiotic and 2) Exercise + Placebo.
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The study is a double-blind, placebo-controlled study.
| Exercise | Behavioral | During the intervention period, all participants will perform 6 weeks of supervised progressive multi-component exercise training consisting of moderate to vigorous aerobic and strength-based exercises (3x/wk.). |
|
| Placebo | Dietary Supplement | Maltodextrin (Globe 18DE Maltodextrin, Ingredion) supplements (10g/day) will be consumed daily mixed with water. |
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Determine the impact of daily consumption of prebiotic combined with regular exercise on fasting insulin compared to control.
| Baseline & 6-week mark |
| Changes in body composition | Determine the impact of daily consumption of prebiotic combined with regular exercise on body composition compared to control. This includes percentage of fat mass and lean mass. | Baseline & 6-week mark |
| Changes in body fat distribution | Determine the impact of daily consumption of prebiotic combined with regular exercise on body fat distribution compared to control. This includes the weight of visceral fat and liver fat in kilograms. | Baseline & 6-week mark |
| Changes in cognition | Determine the impact of daily consumption of prebiotic combined with regular exercise on relational memory, hippocampal function, interference control, and selective attention compared to control. Outcomes will be assessed with computer tasks and participants will be equipped with an electrode cap. | Baseline & 6-week mark |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |