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Prognostic factors determining visual outcomes in patients with posterior polar cataracts and posterior lenticonus are largely unknown. In this trial, the investigators aimed to evaluate the visual outcomes in patients with posterior polar cataracts and posterior lenticonus and try to find out the factors associated with the visual acuity after surgery. Patients enrolled in this study will be followed for at least 6 months and will have study visits at 1 day, 1 week, 1 month, 3 month, 6 month postoperatively.
Congenital cataract patients have a wide range of presentations of lens opacities with different impact on visual function. Polar cataracts are opacities of the subcapsular cortex in the polar regions of the lens. To our knowledge, anterior polar cataracts are usually visually insignificant, however, even a small posterior lens opacity can impair vision because of their close proximity to the macula. Visual impairment could be caused by an opacity that blocks the visual axis, refractive error, posterior lesion-induced optical distortion, or amblyopia. Therefore, surgery is often recommended when visual function is significantly affected. The primary indication for surgical intervention in cataract is poor visual acuity. However, the previous studies have shown that preoperative visual acuity is a poor predictor of improvement in the subjectively experienced quality of vision after cataract surgery. Considering the increased risk for capsule rupture during surgery and the sacrifice of accommodation after cataract surgery in eyes with posterior lens opacities, the decision of surgical intervention must be carefully weighed.
In this trial, the investigators aimed to evaluate the changes of visual function, including visual acuity, modulation transfer function, ocular aberrations in the participants with posterior lens opacities. Moreover, various factors which might be associated with postoperative visual acuity were explored. The participants enrolled in this study will be followed for at least 6 months and will have study visits at 1 day, 1 week, 1 month, 3 month, 6 month postoperatively.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| posterior polar cataracts | Phacomulsification lens removal cataract surgery with Intraocular lens(IOL) implantation were performed in these patients. Drug: Subconjunctival dexamethasone and general anesthesia All patients received subconjunctival dexamethasone (2 mg) during surgery, and all surgeries were performed under general anesthesia. |
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| posterior lenticonus | Phacomulsification lens removal cataract surgery with Intraocular lens(IOL) implantation were performed in these patients. Drug: Subconjunctival dexamethasone and general anesthesia All patients received subconjunctival dexamethasone (2 mg) during surgery, and all surgeries were performed under general anesthesia. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Phacomulsification lens removal cataract surgery with Intraocular lens(IOL) implantation | Procedure | Phacomulsification lens removal cataract surgery with IOL implantation in both two groups |
| Measure | Description | Time Frame |
|---|---|---|
| Visual acuity (BCVA) | Visual acuity (BCVA) measured by ETDRS chart after surgery | 6 month after surgery |
| Stereoacuity | Stereoacuity measured at 40 cm using the Randot stereotests | 6 month after surgery |
| modulation transfer function (MTF) | MTF measured with the Optical Quality Analysis System | 6 month after surgery |
| monochromatic aberrations | monochromatic aberrations measured by the iTrace Dynamic Laser Refraction | 6 month after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Location of the cataracts | divided into central, paracentral, and peripheral | before surgery |
| size of lens lesion | measured by image J |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with congenital posterior polar cataracts or posterior lenticonus who need cataract surgery at the Zhongshan Ophthalmic Center, Sun Yat-sen University in China were included. The patients who had relevant ocular disease other than congenital cataract or could not cooperate to the examinations were excluded. The indication for surgery in all patients was significantly deteriorated visual function and amblyopia treatment failure (decline in CDVA to 20/80 or worse). The study adhered to the tenets of the Declaration of Helsinki. Written informed consent was obtained from each subject.
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| Name | Affiliation | Role |
|---|---|---|
| Weirong Chen, MD, PhD | Zhongshan Ophthalmic Center, Sun Yat-sen University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongshan Ophthalmic Center, Sun Yat-sen University | Guangzhou | China |
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| ID | Term |
|---|---|
| D004343 | Drug Implants |
| ID | Term |
|---|---|
| D003692 | Delayed-Action Preparations |
| D004304 | Dosage Forms |
| D004364 | Pharmaceutical Preparations |
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| before surgery |
| Visual acuity (BCVA) | Visual acuity (BCVA) measured by ETDRS chart before surgery | before surgery |
| Stereoacuity | Stereoacuity measured at 40 cm using the Randot stereotests | before surgery |
| modulation transfer function (MTF) | MTF measured with the Optical Quality Analysis System | before surgery |
| monochromatic aberrations | monochromatic aberrations measured by the iTrace Dynamic Laser Refraction system | before surgery |