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This is a retrospective observational study in the form of a cohort study evaluating the use of pre-operative imaging for the diagnosis of acute appendicitis in a tertiary centre during the first and second waves of the COVID-19 pandemic in the United Kingdom. The study group includes all patients who underwent emergency appendicectomy for suspected acute appendicitis between March 2020 and February 2021, while the control group includes all patients who underwent emergency appendicectomy for suspected acute appendicitis between March 2019 and February 2020. The final histology will be used as primary outcome, as the study hypothesis is that increasing the use of pre-operative imaging will reduce the negative appendicectomy rate.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pandemic Group | All patients who underwent emergency appendicectomy for suspected acute appendicitis between March 2020 and February 2021 |
| |
| Control Group | All patients who underwent emergency appendicectomy for suspected acute appendicitis between March 2019 and February 2020 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pre-operative imaging | Diagnostic Test | Use of pre-operative imaging or the diagnosis of acute appendicitis |
|
| Measure | Description | Time Frame |
|---|---|---|
| Negative Appendicectomy Rate (NAR) | Number of patients with final histology negative for acute appendicitis | Up to 3 weeks post-operatively (when final Histology is ready) |
| Measure | Description | Time Frame |
|---|---|---|
| Post-Operative Length of Stay | Post-operative length of hospital stay (from post-operative day 1) | Assessed on day 30 after the completion of the study |
| Post-Operative Complications Rate | Number of patients who had post-operative complications |
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Inclusion Criteria:
Exclusion Criteria:
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All consecutive patients operated at a tertiary centre
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| Name | Affiliation | Role |
|---|---|---|
| Gerardo Perrotta, MD | University College London Hospitals | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University College London Hospitals NHS Foundation Trust | London | NW1 2BU | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36422811 | Derived | Perrotta G, Geropoulos G, Bhan C. The role of imaging in the diagnosis of acute appendicitis during the COVID-19 pandemic: a retrospective cohort study. Updates Surg. 2023 Jan;75(1):205-208. doi: 10.1007/s13304-022-01426-y. Epub 2022 Nov 24. |
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| ID | Term |
|---|---|
| D001064 | Appendicitis |
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D059413 | Intraabdominal Infections |
| D007239 | Infections |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
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| Within 30 post-operative days |
| D004066 |
| Digestive System Diseases |
| D002429 | Cecal Diseases |
| D007410 | Intestinal Diseases |
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |