Local anesthesia was performed on patients with total knee arthroplasty (TKA) through two different injection sites of local anesthetics and two local anesthetic drug . The pain score of patients after TKA was collected, then the analgesic effect of patients after TKA through two different injection sites and two different local anesthetic drug were analyzed and evaluated.

Inclusion Criteria:

• 1. Patients between the ages of 40-75, who meet the indications for total knee arthroplasty(TKA) surgery, plan to undergo unilateral TKA surgery, can tolerate surgical trauma, and have no surgical contraindications;
• 2. Patients who have good medical obedience and can cooperate to complete the evaluation of various indicators after the operation and continue to receive follow-up;
• 3. There is no contraindications to combined spinal-epidural anesthesia;
• 4. Agree to accept this trial and sign an informed consent form.

Exclusion Criteria:

• 1. Allergic to test drugs;
• 2. Abnormal liver, kidney or heart function;
• 3. People who have chronic pain symptoms in other parts of the body other than the knee joint;
• 4. Patients with a history of multiple operations on the knee joint, or patients with abnormal anatomical structures;
• 5. Patients who cannot perform early functional exercise after unconventional knee replacement or other systemic diseases;
• 6. Cannot communicate with researchers normally.