Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 2R01HD059205-11A1 | U.S. NIH Grant/Contract | View source | |
| SPO #42749 | Other Grant/Funding Number | Stanford Sponsored Projects Number |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | NIH |
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).
To achieve this goal, investigators will use a theoretically-motivated integrated symbolic/non-symbolic (iSNS) intervention with a randomized controlled design to enhance cross-format mapping between symbolic and nonsymbolic representations of quantities. The investigators will develop innovative computational models to investigate individual differences in latent cognitive processes and brain plasticity that contribute to learning, long-term retention, and transfer in children.
The investigators will assess performance in several areas and investigate cognitive and neural mechanisms that support numerical skill acquisition in children with differing levels of math learning abilities.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Integrative Symbolic Non-Symbolic (iSNS) Training | Experimental | Integrative symbolic non-symbolic (iSNS) training: Over a period of 6 weeks, participants will complete activities that progressively strengthen the mapping of symbolic numerical representations to non-symbolic numerical quantities and enhance fluency in symbolic numerical skills. |
|
| Active Comparator: Active Control Intervention (Working Memory Training) | Active Comparator | Active control intervention: Over a period of 6 weeks, participants will complete activities that enhance short-term storage and maintenance of visuospatial or verbal information. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Interventions in Mathematics and Cognitive Skills - Experimental | Other | After study participants have completed screenings to meet our inclusion criteria, participants will take part in the pre-training MRI brain scan (if eligible) and behavioral assessments and will then be assigned to the intervention for 6 weeks. During this training, participants will spend three days each week completing a set of problems at their home on a tablet that we provide them. Participants will receive one-to-one training with a member of our research team once a week. Following the completion of the 6-week training program, participants will be asked to complete a second MRI brain imaging session (for those who completed pre-training MRI) and post-measure appointments in order to assess immediate effects of the training program. Participants will also be invited to return for follow-up testing after six months in order to assess the long- lasting effects of the training program. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in symbolic number comparison task performance (reaction time) | Performance will be measured by children's reaction time (milliseconds) on symbolic number comparison task | Baseline and post-intervention (after 6 weeks) |
| Change from baseline in symbolic number comparison task performance (accuracy) | Performance will be measured by children's accuracy (% trials correct) on symbolic number comparison task | Baseline and post-intervention (after 6 weeks) |
| Change from baseline in non-symbolic number comparison task performance (reaction time) | Performance will be measured by children's reaction time (milliseconds) on non-symbolic number comparison task | Baseline and post-intervention (after 6 weeks) |
| Change from baseline in non-symbolic number comparison task performance (accuracy) | Performance will be measured by children's accuracy (% trials correct) on non-symbolic number comparison task | Baseline and post-intervention (after 6 weeks) |
| Change from baseline in latent cognitive measures of symbolic number comparison task performance (drift rate) | Latent cognitive processing will be measured by drift rate from children's symbolic number comparison task performance | Baseline and post-intervention (after 6 weeks) |
| Change from baseline in latent cognitive measures of symbolic number comparison task performance (post-error adjustment) | Latent cognitive processing will be measured by post-error adjustment from children's symbolic number comparison task performance |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in symbolic addition task performance (reaction time) | Performance will be measured by children's reaction time (milliseconds) on symbolic addition task | Baseline and post-intervention (after 6 weeks) |
| Change from baseline in symbolic addition task performance (accuracy) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Vinod Menon, PhD | Contact | 16507363699 | menon@stanford.edu |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford Cognitive and Systems Neuroscience Laboratory | Recruiting | Palo Alto | California | 94304 | United States |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| Interventions in Mathematics and Cognitive Skills - Active Comparator | Other | After study participants have completed screenings to meet our inclusion criteria, participants will take part in the pre-training MRI brain scan (if eligible) and behavioral assessments and will then be assigned to the intervention for 6 weeks. During this training, participants will spend three days each week completing a set of problems at their home on a tablet that we provide them. Participants will receive one-to-one training with a member of our research team once a week. Following the completion of the 6-week training program, participants will be asked to complete a second MRI brain imaging session (for those who completed pre-training MRI) and post-measure appointments in order to assess immediate effects of the training program. Participants will also be invited to return for follow-up testing after six months in order to assess the long- lasting effects of the training program. |
|
| Baseline and post-intervention (after 6 weeks) |
| Change from baseline in latent cognitive measures of non-symbolic number comparison task performance (drift rate) | Latent cognitive processing will be measured by drift rate from children's non-symbolic number comparison task performance | Baseline and post-intervention (after 6 weeks) |
| Change from baseline in latent cognitive measures of non-symbolic number comparison task performance (post-error adjustment) | Latent cognitive processing will be measured by post-error adjustment from children's non-symbolic number comparison task performance | Baseline and post-intervention (after 6 weeks) |
| Change from baseline in brain activation during symbolic number comparison task performance | Neural activity will be measured during functional magnetic resonance imaging (fMRI) symbolic number comparison task. Data will consist of beta values from individual subject contrast maps for Near vs Far contrast from the whole-brain GLM fMRI analysis. | Baseline and post-intervention (after 6 weeks) |
| Change from baseline in brain activation during non-symbolic number comparison task performance | Neural activity will be measured during functional magnetic resonance imaging (fMRI) non-symbolic number comparison task. Data will consist of beta values from individual subject contrast maps for Near vs Far contrast from the whole-brain general linear model (GLM) fMRI analysis. | Baseline and post-intervention (after 6 weeks) |
Performance will be measured by children's accuracy (% trials correct) on symbolic addition task |
| Baseline and post-intervention (after 6 weeks) |
| ID | Term |
|---|---|
| D060705 | Dyscalculia |
| D002658 | Developmental Disabilities |
| D007859 | Learning Disabilities |
| D000067559 | Specific Learning Disorder |
| D002652 | Child Behavior |
| D001519 | Behavior |
| D003072 | Cognition Disorders |
| D060825 | Cognitive Dysfunction |
| D000072458 | Orientation, Spatial |
| D008224 | Lymphoma, Follicular |
| ID | Term |
|---|---|
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
| D019965 | Neurocognitive Disorders |
| D013037 | Spatial Behavior |
| D008228 | Lymphoma, Non-Hodgkin |
| D008223 | Lymphoma |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D008722 | Methods |
| ID | Term |
|---|---|
| D008919 | Investigative Techniques |
Not provided
Not provided