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Peri-implantitis is a pathological condition associated with plaque that develops around dental implants, characterized by inflammation and progressive bone loss in the peri-implant area. Bleeding on probing, suppuration, increased pathological pocket depths and/or mucosal recessions are seen with radiographic bone loss in peri-implantitis. When evaluated histologically, the lesion extends to the apical part of the pocket epithelium and contains a large amount of plasma cells, macrophages and neutrophils. In the Peri-implant crevicular fluid analysis, which is one of the most important parameters that enable the biochemical and immunological evaluation of the inflammatory state in the peri-implant region, information about the current inflammatory situation can be obtained by evaluating the content of an osmotic inflammatory exudate originating from the vessels in the gingival plexus. Many surgical and non-surgical methods have been proposed for the treatment of peri-implantitis. Mechanical surface debridement, laser application and air abrasives are a part of non-surgical treatment of peri-implantitis. In this study, we examined the effectiveness of diode laser in addition to mechanical debridement with titanium curettes. In our study, we aimed to compare these two treatments biochemically by determining the changes in interleukin-1β, Interleukin-10, Interleukin-17, RANKL, osteoprotegerin, TWEAK and sclerostin biomarkers in Peri-implant crevicular fluid and clinically.
Primary outcome measures (probing depth as clinical parameter) and secondary outcome measures ( collection of gingival crevicular fluid, gingival bleeding time index, gingival index, plaque index and clinical attachment level) asre recorded in baseline, third and sixth month. The change between these parameters is observed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diode Laser | Experimental | At baseline, diode laser is applied to one group. |
|
| Titanium curettes | Active Comparator | At baseline, titanium curettes are used to both of the groups |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diode laser | Device | Diode Laser is applied to one group as an adjunctive therapy. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical parameter probing depth | The primary outcome of the study was the control examination performed 3 months after the first examination. Probing depth was measured with a periodontal probe by the distance between gingival margin and the base of the pocket. The change between these time frames are recorded. | Baseline, 3 months and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Another outcome of the study is the collection of gingival crevicular fluid samples in the 3rd month. | Samples are obtained by means of paper strips placed gently in the gingival groove. These samples are stored at -20 ° C for later analysis by ELISA method. The change between these time frames are recorded. | Baseline, 3 months and 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nazan Ece ERDURAN | Contact | 00905541900462 | nazaneceerduran@gmail.com | |
| Güliz Nigar Güncü | Contact | gngun1@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Güliz Nigar GÜNCÜ, Prof. Dr. | study director | Study Director |
| Abdullah Cevdet AKMAN, Prof Dr | Principal Investigator | Principal Investigator |
| Rahime Meral NOHUTCU |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hacettepe University | Recruiting | Ankara | Turkey (Türkiye) |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 8, 2024 | |
| Reset | Jan 2, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 8, 2024 | Jan 2, 2025 |
| ID | Term |
|---|---|
| D057873 | Peri-Implantitis |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D054023 | Lasers, Semiconductor |
| ID | Term |
|---|---|
| D007834 | Lasers |
| D055096 | Optical Devices |
| D004864 | Equipment and Supplies |
| D055618 | Radiation Equipment and Supplies |
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| Titanium curettes |
| Device |
Non-surgical treatment with titanium curettes were administrated to both groups. |
|
| Gingival bleeding time index |
Bleeding on probing according to the time is recorded. The change between these time frames are recorded. |
| Baseline, 3 months and 6 months |
| Gingival index | The gingival index is graded as follows: 0 = Normal gingiva
| Baseline, 3 months and 6 months |
| Plaque index | 0 = No plaque in the gingival area.
| Baseline, 3 months and 6 months |
| Clinical attachment level | The distance in millimeters from the cemento-enamel junction to the bottom of the pocket. | Baseline, 3 months and 6 months |
| Principal Investigator |
| Principal Investigator |
| Ali Tuğrul GÜR, Phd | Principal Investigator | Principal Investigator |
| Aslı PINAR, Prof Dr | biochemistry | Principal Investigator |