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| Name | Class |
|---|---|
| VSB - Technical University of Ostrava | UNKNOWN |
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The acute phase of the COVID-19 pandemic requires a redefinition of healthcare system to increase the number of available intensive care units for COVID-19 patients. This leads to the postponing of elective surgeries including the treatment of abdominal aortic aneurysm (AAA). The probabilistic rupture risk index (PRRI) recently showed its advantage over the diameter criterion in AAA rupture risk assessment. Its major improvement is in increased specificity and yet has the same sensitivity as the maximal diameter criterion. The objective of this study was to test the clinical applicability of the PRRI diagnostic method in a quasi-prospective observational patient cohort study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| BRRA group | Rupture risk of asymptomatic AAAs in this group was estimated using Biomechanical rupture rist assessment (BRRA). BRRA considers an AAA as a pressure vessel and estimates its risk of rupture by comparing its wall stress to wall strength |
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| Maximal diameter group | Rupture risk of asymptomatic AAAs in this group was estimated by a classical approach based on a maximal diameter. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biomechanical rupture risk assessment | Diagnostic Test | 3D computational model is created from CT angiographic images available during standard AAA diagnostic process. Vascular wall stress is assessed based on the 3D model using Finite element method to identify highly stressed parts of AAA and results are compared to populational wall strength information (gathered from previous large histological study), thus rupture risk (stress/strength ratio) of each particular AAA is estimated. Other relevant factors such as gender, blood pressure, presence of intraluminal thrombus etc. are used during the calculation as well. |
| Measure | Description | Time Frame |
|---|---|---|
| Test the clinical applicability of the BRRA method | Identify the number of number of false positive and false negative cases assessed by BRRA method according to clinical data and compare these data to control group where the decision making process was based only on maximal diameter of AAA | 21 months |
| Measure | Description | Time Frame |
|---|---|---|
| Reduction of time required for AAA assessment | To investigate the feasibility of cooperation between the biomechanical and medical teams in a modified AAA management workflow leading to reduced time required for an AAA assessment | 21 months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients diagnosed with asymptomatic AAA during the COVID-19 pandemic period. During this period an elective surgeries had to be posponed and there was a need for auxiliary diagnostic method able to identify AAAs with high risk of rupture.
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| Name | Affiliation | Role |
|---|---|---|
| Robert Staffa, M.D., Ph.D. | Masaryk University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St. Anne“s University Hospital in Brno | Brno | 65691 | Czechia |
All data are stored in standard patient documentation in study center, anonymized data can be shared on request
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| ID | Term |
|---|---|
| D017544 | Aortic Aneurysm, Abdominal |
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D001014 | Aortic Aneurysm |
| D000783 | Aneurysm |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| D001018 |
| Aortic Diseases |
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |