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This study will explore the expression of PARP-1 in optic neuritis of multiple sclerosis patients.
The data will be collected from Sohag University hospital in the period from the start of August 2021 to the end of December 2021.
The study protocol will be approved by the Scientific Research Ethical Committee, Faculty of Medicine, Sohag University.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | Other |
| |
| MS with optic neuritis | Active Comparator |
| |
| Ms without optic neuritis | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sampling | Genetic | Blood sample for detection of PARP-1 gene and correlate to changes of the optic disc, RNFL and GCC layers of the retina of MS patients |
|
| Measure | Description | Time Frame |
|---|---|---|
| measure PARP-1 mRNA | measure PARP-1 mRNA | 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Optic nerve, RNFL and GCC layer affection by MS | Optic nerve Retinal nerve fibre layer (RNFL) in um ) and Ganglion cell complex (GCC) layer affection in um by MS in correlation to PARP-1 mRNA | 2 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Elshimaa A.Mateen | Sohag | 82511 | Egypt |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |