Beta Blocker Effects in Traumatic Brain Injury

Beta Blocker Effects on Patients With Traumatic Brain Injury

The study will be conducted on polytrauma patient who are admitted from emergency room or postoperative with head trauma to evaluate effects of beta blocker on patients with TBI.

The study will be conducted on polytrauma patient who are admitted from emergency room or postoperative with head trauma . Patients will be randomly assigned into two groups by sealed envelope technique into two equal groups.

Parameters assessment:

• Length of ICU stay
• Length of total hospital stay
• CT scan to exclude another intracranial hemorrhage or increase in hemorrhage
• Functional status will be assessed using the GCS
• Hemodynamic data ( bl.p / hr )
• Crystalloid volume that patient need in 24h
• Mortality rate

Inclusion Criteria:

• GCS preoperative >10
• Abbreviated Injury Scale (AIS) >3
• Length stay in ICU >48 h

Exclusion Criteria:

• Hypersensitivity to propranolol
• Asthmatic patient
• COPD
• History of smoking
• Any cardiac problems eg: ( heart failure or HB )
• pheochromocytoma
• Pregnant patient
• Length stay <48h
• Death within 48 h of admission
• Patient who previously received any beta blocker at home.
• Symptomatic Bradycardia <60 b/m (sick sinus syndrome)
• Hemodynamic unstable patients