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| Name | Class |
|---|---|
| Lund University | OTHER |
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Observational retrospective study of patients in need of acute surgical care admitted to Skåne University Hospital between 2009 and 2019.
At Skåne University Hospital approximately 6000 individuals are treated for acute abdominal diseases each year. Given the high number of patients, there is an urgent need to optimize acute surgical care. Lower complication rates would decrease hospital stay, health care costs as well as personal suffering.
Assessment instruments for risks and frailty are not validated for the acute setting and the investigators hypothesize there is room for improvement in prophylactic interventions and risk assessment. The investigators will study cohorts of patients with three different surgical diagnosis: acute pancreatitis, gastrointestinal bleeding and perforated ulcer aiming to identify risk factors for complications or death and to investigate assessment tools in this population. Using propensity score analysis, the investigators will try to identify treatment options associated with better outcome for subcohorts defined by frailty, comorbidity, age or gender. Specific factors of interest include: time to- and kind of treatment, handling of ongoing pharmacological therapy (anticoagulants, corticosteroids) and need for further treatments on a long time basis. The results from this project will be used in a future prospective study where prophylactic treatments and specific treatment options are studied.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mild acute pancreatitis | Patients treated with mild acute pancreatitis during the study period |
| |
| Moderate acute pancreatitis | Patients treated with moderate acute pancreatitis during the study period |
| |
| Severe acute pancreatitis | Patients treated with severe acute pancreatitis during the study period |
| |
| Acute gastrointestinal bleeding | Patients treated with acute gastrointestinal bleeding during the study period |
| |
| Perforated ulcer | Patients treated with perforated ulcer during the study period |
| |
| Older than 70 years |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Observational study of different treatments and time to treatment | Other | Different treatment based on the clinical decision |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | Defined by Swedish registers | 5 years |
| Reintervention | Defined by medical records | 5 years |
| Recurrent disease | Defined by medical records | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Lengths of hospital stay | defined by medical records | 5 years |
| Number of interventions | defined by medical records | 5 years |
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Inclusion Criteria: Patients admitted to Skåne University hospital in need of acute surgical care -
Exclusion Criteria: Below 18 years old
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All patients admitted to to Skåne University hospital in need of acute surgical care between 2009-2019
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sara Regnér, PhD | Contact | 040 33 10 00 | sara.regner@med.lu.se | |
| Jenny Eckner, PhD | Contact | 040 33 10 00 | jenny.eckner@skane.se |
| Name | Affiliation | Role |
|---|---|---|
| Sara Regnér, PhD | Region Skane | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Skåne University Hospital | Recruiting | Malmö | Skåne County | 20502 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40931336 | Background | Forsberg-Puckett A, Wurm Johansson G, Regner S. Presentation of gastrointestinal bleeding in patients with antithrombotic therapy, results from a consecutive retrospective cohort. Scand J Trauma Resusc Emerg Med. 2025 Sep 10;33(1):146. doi: 10.1186/s13049-025-01431-1. |
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IPD will be shared after publication of studies from this trial upon request from publishers or other researchers. Only coded data will be shared and all sharing will be done according to the GDPR regulations.
Study protocol will be available during 2022. SAP will be available during 2023.
After papers from this study have been published Upon request from publishers or researchers with a motivated scientific purpose or a motivated research question Only in accordance with GDPR regulations
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Patients older than 70 years
|
| Less than 70 years | Patients younger than 70 years |
|
| Prothrombotic medications | Patients on prothrombotic medications |
|
| Frail patients | Patients with increased frailty score |
|
| Reintervention group | Patients in need of reintervention |
|
| complications | defined by medical records and Swedish Registers | 5 years |
| ID | Term |
|---|---|
| D000073496 | Frailty |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D061665 | Time-to-Treatment |
| ID | Term |
|---|---|
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
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