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lack of resources and staff
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The purpose of this study is to assess the low-intensity focused ultrasound pulsation (LIFUP) neuromodulation on emotion processing in healthy individuals, and to assess the overall safety of the LIFUP to stimulate or inhibit brain activity in healthy volunteers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LIFUP sonication to the amygdala | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LIFUP sonication to the amygdala | Device | LIFUP sonication to amygdala will be performed. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in amygdala activity indicated by functional magnetic resonance imaging (fMRI) scan blood oxygen-level-dependent (BOLD) signal | baseline, 5 mins post-LIFUP sonication | |
| Changes in brain resting state functional network as indicated by fMRI scan connectivity measures | baseline, 10-20 mins post-LIFUP sonication |
| Measure | Description | Time Frame |
|---|---|---|
| Change in performance on Reward Task | baseline, 1-hour post-LIFUP sonication | |
| Tolerability of LIFUP sonication as assessed number of adverse events | baseline, immediately after LIFUP sonication |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jair Soares, MD, PhD | The University of Texas Health Science Center, Houston | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Texas Health Science Center at Houston | Houston | Texas | 77030 | United States |
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| ID | Term |
|---|---|
| D003865 | Depressive Disorder, Major |
| D003863 | Depression |
| D001523 | Mental Disorders |
| ID | Term |
|---|---|
| D003866 | Depressive Disorder |
| D019964 | Mood Disorders |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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