Transcranial Low Intensity Focused Ultrasound Neuromodulation as a Probe to Study Human Emotion and Cognitive Function

Transcranial Low Intensity Focused Ultrasound Neuromodulation as a Probe to Study Human Emotion and Cognitive Function

The purpose of this study is to assess the low-intensity focused ultrasound pulsation (LIFUP) neuromodulation on emotion processing in healthy individuals, and to assess the overall safety of the LIFUP to stimulate or inhibit brain activity in healthy volunteers.

Inclusion Criteria:

• Must be right-handed
• Must be illicit drug-free at the time of scanning as appropriate (verified by negative urine drug screen)
• Must be healthy (without medical, neurological, psychiatric illness)
• Must be psychotropic medication free (≥ 14 days)

Exclusion Criteria:

• Must not be a smoker
• Females must not be pregnant or nursing
• Must not suffer from claustrophobia
• Must not meet exclusion criteria for MRI scanning (i.e., non-fixed magnetizable objects)
• Must not have ongoing, chronic, or relapsing/remitting medical, psychiatric,or neurological illness as determined by a combination of history, medical record, and/or examination.