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| ID | Type | Description | Link |
|---|---|---|---|
| 2021-A02184-37 | Other Identifier | ANSM |
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Regular physical activity (PA) is associated with maintaining body composition, increased cardiorespiratory capacity, muscle mass and bone mineral density. In the event of a cancer, the development of physical capacities and metabolism may therefore be disturbed by cancer, these associated treatments (chemotherapy, radiotherapy and hematopoietic stem cell transplantation) but also undernutrition and the reduction in physical activity or even a sedentary lifestyle.
Although the benefits of PA in oncology are now well identified for adult populations, studies are still rare in the population of children, adolescents and young adults, and the results are still difficult to generalize. As a result, there is no recommendation on the practice of physical activity in pediatric oncology or adolescents and young adults and the levels of physical activity of cured patients remain lower than those of the general population.
Fitness is a marker of health in adults as well as in adolescents. Physical condition is a set of components such as cardiorespiratory capacity (transport and use of O2), body composition (distribution of bone, muscle and fat masses) and muscle function (strength, power, fatigue, energy metabolism) .
The investigators hypothesize that, compared to young adults, recovered from lymphoma are expected to exhibit impaired physical condition, due to physical deconditioning.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy controls | Active Comparator | sex and age matched healthy controls |
|
| young adults recovered from lymphoma or Hodgkin's disease | Experimental | young adults recovered from lymphoma or Hodgkin's disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Indirect calorimetric test during submaximal exercise | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| fat oxidation rate | maximum rate of lipid oxidation (in mg/ml) | day at 11:30 am during one day |
| Measure | Description | Time Frame |
|---|---|---|
| rest metabolism | energy expenditure at rest in kcal. | at 08:00 am in fasted condition during one day |
| blood insulinemia | blood value of insulin in pmol/L |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Justina Kanold | University Hospital, Clermont-Ferrand | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Clermont-Ferrand | Clermont-Ferrand | 63000 | France |
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| ID | Term |
|---|---|
| D008228 | Lymphoma, Non-Hodgkin |
| D006689 | Hodgkin Disease |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D008223 | Lymphoma |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008232 | Lymphoproliferative Disorders |
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| ID | Term |
|---|---|
| D002302 | Cardiac Output |
| D001823 | Body Composition |
| D006403 | Hematologic Tests |
| D061725 | Accelerometry |
| ID | Term |
|---|---|
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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group 1: healthy controls group 2 : young adults recovered from lymphoma or Hodgkin's disease
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|
|
| at 07:30 am in fasted condition during one day |
| blood N-terminal pro-B natriuretic peptide | blood N-terminal pro-B natriuretic peptide level in g/L | at 07:30 am in fasted condition during one day |
| blood troponin | blood troponin level in g/L | at 07:30 am in fasted condition during one day |
| blood lipids | blood lipids level in g/L | at 07:30 am in fasted condition during one day |
| blood glucose | blood glucose level in g/L | at 07:30 am in fasted condition during one day |
| Body composition: fat | percentage of fat | at 07:30 am during one day |
| Body composition: lean mass | percentage of lean mass | at 07:30 am during one day |
| cardiac output | Systolic Ejection Volume in mL evaluated at rest and during submaximal exercise | at 11:30 am during one day |
| peripheral quantitative computed tomography | Cross-sectional area of thigh muscles and intermuscular adipose tissue were assessed for muscle at 40% of the length between the greater trochanter and the mid-patella of the right leg | at 10:45 am during one day |
| physical condition | 3 min step-test (number of ascent / descent step) | at 08:45 am during one day |
| physical capacity | chair test (time in second held in position) | at 08:45 am during one day |
| physical activity level | daily energy expenditure (in Kcal) | from day 2 to day 5 |
| sedentary level | total sedentary time (in min) evaluated by accelerometer for 4 days | from day 2 to day 5 |
| D008206 |
| Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
| D001519 | Behavior |
| D006439 | Hemodynamics |
| D002320 | Cardiovascular Physiological Phenomena |
| D002943 | Circulatory and Respiratory Physiological Phenomena |
| D001669 | Biochemical Phenomena |
| D055598 | Chemical Phenomena |
| D008660 | Metabolism |
| D001824 | Body Constitution |
| D010829 | Physiological Phenomena |
| D019411 | Clinical Laboratory Techniques |
| D008919 | Investigative Techniques |