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| Name | Class |
|---|---|
| Institut National de la Santé Et de la Recherche Médicale, France | OTHER_GOV |
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Pregnancy pathologies can occur from implantation until childbirth. The investigators are interested in the development mechanisms of these pathologies and aim to develop therapies to treat them.
The investigators need to collect samples, especially placental samples, following abortions and term and premature deliveries. Abortions will allow investigators to have non-pathological placental material up to 13 weeks. This material will serve as a reference for the understanding of the histological changes that occur in normal placentas collected at term of pregnancy. The latter will, in turn, be compared with the placentas collected during premature deliveries. Also, the abortion product will be cultivated in an environment mimicking the pathology of pre-eclampsia. This study will allow investigators to advance their understanding of the pathophysiological mechanisms of the placenta. The investigators are internationally recognized for their research on these pathologies.
Pregnancy pathologies can occur from implantation until childbirth. Clinical and scientific investigators are interested in the study of the mechanisms of development of these pathologies and aim to develop therapies to treat them.
The investigators need to collect samples, especially placental samples, following abortions, term, and premature deliveries. Abortions will allow investigators to have non-pathological placental material up to 13 weeks. This material will serve as a reference for understanding the histological changes that occur in normal placentas collected at term of pregnancy. The latter, will in turn, be compared with the placentas collected during premature deliveries. Also, the abortion product will be cultivated in an environment mimicking the pathology of preeclampsia. This study will allow investigators to advance the understanding of the pathophysiological mechanisms of the placenta.
The investigators are internationally recognized for its research on these thematic.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal, pathological IVG | We will use placenta and fetal memebranes collected from first trimester termination of pregnancy. This will constitute group IVG. |
| |
| Normal and pathological term | We will also use the same specimens collected from third trimester pregnancies . We will call this group normal and pathological..... Ã finaliser |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Histology | Diagnostic Test | Collect the placenta and fetal membranes and perfor either tissue culture or fixation for further analyses |
|
| Measure | Description | Time Frame |
|---|---|---|
| To better characterize pregnancy pathologies from implantation to childbirth | Comparison of the frequencies (in percentage) of the histological differences of the placenta and its appendages in patients with pathological and normal pregnancies (histological differences of normal pregnancies versus pathological pregnancies. | Analyses will be performed on each collected sample. The measurement is assessed for up to 6 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Link between the frequencies of histological aberrations and worsening of the pathology | Comparison of the severity of the pathology according to the frequencies of aberrations | Assessement of the link between the frequencies of histological aberrations and worsening of the pathology will be assessed on the final cohort; This will take up to 3 hours for each aberration. |
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Inclusion Criteria:
Adult women
Exclusion Criteria:
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The study will include normal and pathological pregnant women from first to third trimester. A finaliser
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pascale Hoffmann, MD PhD | Contact | 0476769223 | PHoffmann@chu-grenoble.fr | |
| Nadia Alfaidy, PhD | Contact | 0033632073234 | nadia.alfaidy-benharouga@cea.fr |
| Name | Affiliation | Role |
|---|---|---|
| Pascale Hoffmann, MD PHD | Grenoble hospital | Principal Investigator |
| Nadia Alfaidy, PhD | INSERM U1292 | Study Director |
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| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| D047928 | Premature Birth |
| D005317 | Fetal Growth Retardation |
| D009389 | Neovascularization, Pathologic |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D016626 | Shadowing Technique, Histology |
| D007150 | Immunohistochemistry |
| ID | Term |
|---|---|
| D013194 | Staining and Labeling |
| D016591 | Histocytological Preparation Techniques |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
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Placenta and fetal membrane from normal and pathological pregnancies
|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D005315 | Fetal Diseases |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D006130 | Growth Disorders |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D008679 | Metaplasia |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D006652 | Histological Techniques |
| D008919 | Investigative Techniques |
| D006651 | Histocytochemistry |
| D007158 | Immunologic Techniques |