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SARS-COV-2 infection can progress to acute respiratory distress syndrome and require hospitalization in the ICU in 5-20% of affected patients. Age is a major risk factor for developing a severe form and for death. ARDS related to SARS-COV-2 has specific features, including the need for long mechanical ventilation and length of stay and the use of corticosteroid therapy. These specificities are responsible for significant morbidity (neuromyopathy, delirium, post-resuscitation syndrome) and mortality during the first wave (46% at 3 months for the population of patients aged 70 years and over). To investigator's knowledge, no study has evaluated the prognosis in the ICU and the long-term functional outcome of elderly people admitted for a severe or critical form of COVID-19 since the major changes in management (dexamethasone, screening for thrombo-embolic complications, use of high-flow oxygen therapy as first-line treatment...).
Investigator therefore propose a 1-year follow-up of a cohort of patients aged 70 and over hospitalised in a conventional service or in intensive care for a severe or critical form of COVID-19. The objectives are to describe the prognosis and functional outcome of hospitalized elderly patients with severe COVID-19.
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| Measure | Description | Time Frame |
|---|---|---|
| Mortality of patients aged 70 years and over 1 year after diagnosis of SAR-COV2 infection | The mortality was evaluated by the proportion of patients aged 70 years and over who died 1 year after diagnosis of SARS-CoV-2 infection who had severe acute respiratory failure defined by at least 4 L/min of oxygen therapy | 1 year after diagnosis of SarS-CoV-2 |
| Measure | Description | Time Frame |
|---|---|---|
| Overall hospital mortality among included patients | Mortality was evaluated by proportion of patients included who died during their stay at the participating center | during hospitalization |
| In-hospital mortality among patients admitted to and not admitted to intensive care |
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Inclusion Criteria:
Exclusion Criteria:
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Patients aged 70 years and over with severe COVID-19
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu Angers | Angers | 49000 | France | |||
| Centre Hospitalier Du Mans |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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Mortality was ecaluated by proportion of patients not admitted to intensive care who died during their stay in the participating center and proportion of patients admitted to intensive care who died in intensive care and during their stay in the participating center |
| end of hospitalization |
| Mortality 1 year after diagnosis of SARS-CoV-2 infection in patients who were discharged alive from hospital in the overall cohort and according to whether or not they were admitted to intensive care. | Mortality was evaluated by Proportion of patients who died 1 year after diagnosis of SARS-CoV-2 infection among subjects included and discharged alive from the participating center, in the overall cohort and then according to whether or not they were admitted to intensive care. | 1 year after diagnosis of SarS-CoV-2 |
| Outcome for patients admitted and discharged alive from hospital in terms of Quality of life | Quality of life was evaluated by Medical Outcome Study Short Form 36 (SF 36) | 1 year after diagnosis of SarS-CoV-2 |
| Outcome for patients admitted and discharged alive from hospital in terms of functionnal status | Functionnal status was evaluated by Activities of Daily Living Scale (from 0 to 6), by Clinical Fragility Score - CFS (7 levels of frailty (from excellent health to severe frailty)) and proportion of patients institutionalized in residential care facilities for dependent elderly people (EHPAD) or in long-term care units (USLD) | 1 year after diagnosis of SarS-CoV-2 |
| Hospital care for patients not admitted to intensive care | Proportion of patients admitted to intensive care and not admitted to intensive care | during hospitalization |
| Risk factors associated with 1-year outcomes in patients surviving hospitalization in the overall cohort and in the cohort of patients admitted to intensive care. | The outcome for patients will be defined as good prognosis (patient alive with an ADL score ≥ 4) and poor prognosis (patient alive with an ADL score < 4 or deceased patient). | 1 year after diagnosis SARS-CoV-2 |
| Le Mans |
| 72000 |
| France |
| Chu Rennes | Rennes | 35000 | France |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |