It was conducted a prospective study with a series of 50 patients treated by intramedullary nail using Clodronic acid and Vitamin D (study group including 25 patients) and patients with the same fractures treated with Vitamin D alone (control group including 25 patients).

One independent observer performed clinical, biochemical and functional evaluations at T0 (1st day post-surgery) and at T1 (12 months later) Biochemical markers (serum calcium level, serum phosphate level, PTH (parathormone), Vitamin D, serum C-terminal telopeptide), VAS (Visual Analogic Scale) and HHS (Harris Hip Score) score, and femur densitometric views were administered at each evaluation.

Inclusion Criteria:

• femur fractures type 31-A1, A2, (Muller ME, Nazarian S, Kock P et al.);
• age 60 - 85 years;
• co-operative patients;
• Body Mass Index (BMI) < 30 Kg/m²;
• patients treated by intramedullary nailing surgery (PFNA Synthes®);
• patients with osteoporosis disease if T-Score< -2,5;

Exclusion Criteria:

• patients with heart, kidney, neurological diseases;
• patients with metabolic and systemic disease (rheumatoid arthritis, diabetes mellitus);
• previous surgery or severe osteoarthritis of lower limbs;
• specific drugs treatments such as anticoagulants or psychiatric drugs.

Fifty (50) patients referring to the Orthopaedic and Trauma Unit of the local University Hospital between May 2019 and March 2020 with lateral fragility fracture were prospectively recruited.