This study evaluates the safety and efficacy of QTORIN 3.9% rapamycin anhydrous gel in the treatment of adults with Pachyonychia Congenita. This study includes a screening period, baseline period and 6-month treatment period.

Key Inclusion Criteria:

• Adult patients, 18 years or older (16 years or older in the UK)
• Diagnosed with Pachyonychia Congenita (PC), genetically confirmed

Key Exclusion Criteria:

• Any history of allergy or hypersensitivity to sirolimus, or sirolimus-like medications.
• Any significant concurrent condition (including conditions involving or inferior to the ankle) that could adversely affect the patient's participation and/or the assessment of the safety and efficacy in the study.
• Participation in any other interventional clinical research trial within 30 days prior to the screening visit or during the patient's participation in this study