Determination of Vaginal Colonization and the Effect of an Oral Probiotic (PROSALVAG)

Study to Determine Vaginal Colonization and Effect of an Oral Probiotic That Contains L.Rhamnosus, L. Plantarum and L. Crispatus in Women (PROSALVAG)

The aim of this study is to determine the efficacy of an oral nutraceutical with probiotics in restore vaginal health.

After being informed about the study, all patients meeting the inclusion/exclusion criteria and giving written informed consent will receive a nutraceutical containing L. rhamnosus, L. plantarum and L. crispatus once daily.

Inclusion Criteria:

• Aged: 35-43 years old
• Vaginal pH > 4,5 and low Lactobacillus count or Nugent score of 4-6
• With interest in getting pregnant and ideally in IVF waiting list
• History of recurrent genitourinary infections

Exclusion Criteria:

• Any pathology that interferes with the study
• Current intake of food supplements or probiotics
• Current intake of contraceptives
• Use of oral or vaginal probiotics in the last 6 months
• Hypersensitivity to any of the components of the studied product
• Current vaginal infection
• Pregnant women
• Breastfeeding
• Use of intrauterine device
• Use of spermicide
• Use of cervical caps as hormonal therapy