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| Name | Class |
|---|---|
| McGill University | OTHER |
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Lower third molar extraction is one of the most common treatments in oral surgery practice. It is a treatment with inherent complications such as postoperative pain, swelling or trismus. In order to minimize disconfort after extraction, analgesic and anti-inflammatory medication is prescribed. Recently, it is seen that circadian rhythm may play an important role on drugs metabolism, modulating its effect depending on the moment of administration.
The aim of the study is to analyze if dosage modification of a Non Steroideal Anti-Inflammatory (dexketoprofen) affects on postoperative pain, swelling and open mouth limitation according the circadian clock
A randomized crossover split-mouth clinical trial will be performed. After third molar extractions, patients will be prescribed randomly in one side intake morning medication dosage while the contralateral side will be prescribed a night dosage. Moreover, a blood sample will be obtained to analyze the inflammatory profile.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Morning dosage | Experimental | Dexketoprofen pill at morning; Placebo at night |
|
| Night dosage | Experimental | Placebo pill at morning; Dexketoprofen at night |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexketoprofen 25 MG | Drug | Pill at morning |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Post operatory pain | Postoperatory pain with Visual Analogue Scale (VAS: 0 (no pain) to 10 (worst pain)) | From the day of the surgical procedure to the seventh-day |
| Measure | Description | Time Frame |
|---|---|---|
| Swelling | Distance from tragus to pogonion | Baseline and post operatory (day 1, day 3, day 7) |
| Measure | Description | Time Frame |
|---|---|---|
| Trismus | Open mouth limitation in milimiters, interincisal distance | Baseline and post operatory (day 1, day 3 and day 7) |
| Inflammatory profile for IL-1B, IL-6, IL-8, IL-10, TNF alpha | Blood sample analysis for inflammatory cytokines in IU/ml by ELISA test (enzyme-linked immunoassay) |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCM | Madrid | 28040 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41510697 | Derived | Perez-Gonzalez F, Abusamak M, Ruiz LV, Saez-Alcaide LM, Al-Waeli H, Tamimi F, Garcia-Denche JT. Dexketoprofen Time-Dependent Administration After Third Molar Extraction: A Pilot Randomized Cross-Over Controlled Trial. Clin Exp Dent Res. 2026 Feb;12(1):e70163. doi: 10.1002/cre2.70163. |
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| ID | Term |
|---|---|
| D014095 | Tooth, Impacted |
| D014313 | Trismus |
| D010146 | Pain |
| ID | Term |
|---|---|
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
| D013035 | Spasm |
| D020879 | Neuromuscular Manifestations |
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| ID | Term |
|---|---|
| C118296 | dexketoprofen trometamol |
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| Dexketoprofen 25 MG | Drug | Pill at night |
|
|
| Baseline, day 3 and day 7 |
| D009461 |
| Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |