Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction

Effect of Beta-blocker Discontinuation on Functional Capacity and Cardiac Hemodynamics in Patients With Heart Failure With Preserved Ejection Fraction

This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.

This is a prospective pilot study to evaluate changes before and 4 weeks(+/- 1 week) after beta-blocker withdrawal in 30 HFpEF patients. The study involves 2 visits that are 4 weeks apart. The first study visit will occur at a standard of care clinic visit and the second visit will be a research visit to fill out questionnaires and perform the limited echocardiogram. No long term follow up beyond the 2nd visit.

Inclusion Criteria:

• Stable HFpEF patients with NYHA Class II-III or elevated BNP ≥100
• N=30 (Target: 30).
• Age: 50 ~ 80 years.
• ECHO evidence of EF ≥50% and Grade 2 or 3 diastolic dysfunction.
• Chronic loop diuretic use
• Currently on beta-blocker

Exclusion Criteria:

• Beta blocker was prescribed for treating other cardiac conditions such as atrial fibrillation or coronary artery disease.
• Heart rate > 100 bpm
• Recent hospitalization due to HF within 3 months
• Non-English speaker