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The aim of the study is to assess the impact of pharmacist led mobile application on adherence and efficacy of medication in chronic kidney disease patients
This is a prospective randomized two group pharmacist-led interventional study that will be conducted in a private nephrology clinic. The study will involve introduction of the mobile phone applications to chronic kidney disease patients to improve their adherence to the prescribed medications.
Recruited patients will be randomly divided in two groups; intervention group and control group, with baseline evaluation of outcomes to be measured.
Control group will be provided with usual care. Intervention group will be provided in addition to the usual care, with an access to the mobile application after a simple training for app usage. Both groups will be followed for a period of 3 months.
The study will include the development, validation and the testing for evaluating the specially designed mobile application.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group | No Intervention | Control group will be provided with usual care. Intervention group will be provided in addition to the usual care, with an access to the previously described mobile application | |
| Intervention Group | Experimental | Intervention group will be provided in addition to the usual care, with an access to the mobile application |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mobile Application | Other | mobile phone applications directed to chronic kidney disease patients to improve their medication. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in medication adherence | Using a medication adherence questionnaire. | Change from baseline at 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in estimated glomerular filtration rate/ creatinine clearance | Calculated using serum creatinine lab results obtained from clinic. | Change from baseline at 3 months |
| Change in systolic and diastolic blood pressure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Shaza Gamal, Bsc | Teaching Assistant | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Private Clinic | Cairo | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40447835 | Derived | Gamal S, Elseasi AMA, Sabry NA, Farid SF. Impact of pharmacist led mobile application on medication adherence and efficacy in chronic kidney disease. NPJ Digit Med. 2025 May 30;8(1):325. doi: 10.1038/s41746-025-01742-8. |
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| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| D055118 | Medication Adherence |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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To be measured in clinic.
| Change from baseline at 3 months |
| Change in HbA1c | Lab results obtained from clinic. | Change from baseline at 3 months |
| Change in mobile application usability and acceptability by patients | Using System Usability Scale (SUS) questionnaire. (scale 0-100 with higher score meaning better usability) | Change from baseline at 3 months |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010349 | Patient Compliance |
| D010342 | Patient Acceptance of Health Care |
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |
| D001519 | Behavior |