Mindfulness-based Intervention for People With Parkinsonian Tremor

Pilot Study of the Ambulatory Monitoring Evaluation of a Mindfulness Meditation Programme in Parkinsonian Tremor

Mindfulness meditation is an approach that has shown interest in treatment of anxiety in Parkinson's disease. This pilot study aims to assess a more specific effect on tremor using Essential Tremor Embarrassment Assessment and inertial sensors allowing monitoring during sessions and in daily life. This study will focus on 20 patients (10 with and without Mindfulness based intervention and will aim to develop the interface and demonstrate proof of concept before setting up a controlled study

Methodology: Randomized, pilot study comparing 2 parallel arms (Mindfullness group versus group with routine care).

Number of patients:20

Patient selection: patients with severe rest tremor

Duration of project: 12 months

Schedule visit: 4 visits in 6 months

Inclusion Criteria:

• Parkinson disease
• Hoehn st and yahr stage <or = 3
• Age between 35 and 85 years old
• Treatment stabilized for at least 3 months
• Disturbing parkinsonian tremor of the upper limb (item MDS -UPDRS 2.10> 1) and lasting 2 to 6 hours per day
• patients with internet access

Exclusion Criteria:

• Presence of disturbing dyskinetic movements (Item MDS-UPDRS4.2> 1)

• Patient who has already practiced meditation in the last 5 years

• Untreated major depressive episode

• Hallucinations (Item MDS-UPDRS1.2> 1))

• Psychotic disorders - Confusional syndrome

• presence of signs in favor of an atypical parkinsonian syndrome (oculomotor impairment, early falls, hallucinations, MoCA <20, early dysautonomia)

• adult protected by law (guardianship, curatorship or under legal protection)

  • deprivation of liberty by judicial or administrative decision
  • high probability of non-compliance with the protocol or abandonment during the study

• refusal to sign informed consent

• Pregnant or breastfeeding woman

• Lack of social coverage.