Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Negative symptoms and cognitive dysfunction are of importance for the prognosis of the patients of schizophrenia. Based on the hypothesis that deep transcranial magnetic stimulation(dTMS) on prefrontal cortex #PFC# could down-regulate the glutamate level of PFC and regulate the functional network in patients with treatment resistance schizophrenia,this research plan to utilise multimodal functional magnetic imaging method(including structural MRI,resting-state functional magnetic resonance imaging and 1H-MRS) to investigate therapeutic efficacy of high-frequency deep transcranial magnetic stimulation on SZ patients symptoms,as well as to elucidate the correlation between treatment effects and glutamate level of PFC
This study includes 87 treatment resistance schizophrenia patients. This study will investigate 1)abnormalities of the glutamate level of PFC in patients with schizophrenia compared to healthy controls by using 1H-MRS technique. 2)potential modulation effects of deep transcranial magnetic stimulation(dTMS) on prefrontal cortex function of patients with schizophrenia. 3)the therapeutic efficacy of dTMS on cognitive impairments and other psychotic symptoms of patients with schizophrenia by adopting cognitive function and psychotic symptoms evaluation,as well as to explore the optimal dTMS treatment pattern on cognitive function.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sham dTMS | Sham Comparator | 29 patients will be randomly allocated into this group,they will receive sham stimulation. |
|
| dTMS 20Hz | Active Comparator | 29 patients will be randomly allocated into this group,they will receive real stimulation. |
|
| dTMS iTBS | Active Comparator | 29 patients will be randomly allocated into this group,they will receive real stimulation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| deep transcranial magnetic stimulation with H1 coil | Device | Sham deep transcranial magnetic stimulation on PFC .Duration:40 days. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in Positive and Negative Syndrome Scale(PANSS) | Change from baseline in Positive and Negative Syndrome Scale(PANSS) after dtms treat 40 days | baseline,24 hours after the dTMS treatment,40 days |
| Change from baseline in MATRICS Consensus Cognitive Battery | MATRICS Consensus Cognitive Battery | baseline,24 hours after the rTMS treatment,40 days |
| Measure | Description | Time Frame |
|---|---|---|
| Change of PFC neurogenesis | Quantify neural stem cells in hippocampal by using H1-MRS | baseline,24 hours after the dTMS treatment,40days |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dengtang Liu, M.D. | Contact | 8618017311138 | erliu110@126.com |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Mental Health Center | Recruiting | Shanghai | China |
Not provided
Not provided
Not provided
Not provided
Not provided
| High frequency deep transcranial magnetic stimulation with H1 coil | Device | high frequency(20Hz) deep transcranial magnetic stimulation on PFC .Duration:40 days. |
|
| iTBS deep transcranial magnetic stimulation with H1 coil | Device | iTBS deep transcranial magnetic stimulation on PFC .Duration:40 days. |
|
| ID | Term |
|---|---|
| D000090663 | Schizophrenia, Treatment-Resistant |
| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided