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The aim of the study is to determine the effect of resistance training (RT) combined with time-restricted eating (TRE) or normal diet (ND) on muscle mass, and strength. Additionally, the study will compare between TRE and ND and its effects on cardiometabolic health, mitochondria function and body composition among people with metabolic syndrome.
In this randomized controlled trial, 50 males with metabolic syndrome (elevated waist circumference, blood pressure, triglycerides, fasting glucose and low high-density lipoprotein cholesterol) between the age of 40-60y and with BMI between 25-33 kg/m2 will be randomized to either TRE+RT (n=25) or ND+RT (n=25). All participants will perform supervised and monitored RT three time per week for the 10 weeks of intervention Study measurements; Changes in body composition, muscle mass and adipose tissue distribution will be measured by 3-Tesla magnetic resonance imaging (MRI), dual energy x-ray absorptiometry (DXA), air displacement plethysmography (BODPOD) and Bioelectrical Impedance analysis (BIA). Muscular Strength will be assessed. Blood samples, including lipid and glycemic profile. muscle biopsy taken from the vastus lateralis muscle.
Primary aim. Determine the effect of TRE or ND, combined with RT training, on muscle mass and strength as adaptive response to 10 weeks of intervention among people with metabolic syndrome.
Secondary aims. Determine the effect of TRE combined with RT on cardiometabolic health lipid profile and HbA1C (C), Mitochondria function and oxygen consumption (D) and Body composition assessment (E).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Time-restricted eating | Experimental | Participants in the TRE group will be instructed to consume all meals between 12pm to 8pm (8 h eating window with 16 h of fasting) |
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| Normal Diet (ND) | Experimental | The ND group will consume all meals between 6 am - 10 pm (16 h eating window with 8 h of fasting, ad-libitum) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Normal Diet | Other | All praticipants in ND will perform supervised and monitored RT three time per week for the 10 weeks of intervention. The ND group will consume all meals between 6 am - 10 pm (16 h eating window with 8 h of fasting, ad-libitum). |
| Measure | Description | Time Frame |
|---|---|---|
| Primary aim muscle mass | Muscle mass volume using MRI (cm3) | 10 weeks |
| Primary aim free fat mass | Free fat mass will be mesured in in kg using DXA , BOD POD and BIA | 10 weeks |
| Primary aim Maximum strength | Maximum strength by one-repetition maximum (kg) using two exercise (bench press, hack squat) | 10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Secondary aims Cardiometabolic profile | Cardiometabolic profile [glucose (mg/dl), total cholesterol (mg/dl), HDL (mg/dl), LDL (mg/dl), TG (mg/dl)] will be mesured using blood test | 10 weeks |
| Secondary aims body composition assessment |
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Inclusion Criteria:
Exclusion Criteria:
Self-representation of gender identity.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yftach Gepner, Ph.D. | Contact | 0506828501 | gepner@tauex.tau.ac.il | |
| Shay Efrati, MD | Contact | 0549212866 | efratishai@outlook.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tel Aviv University | Recruiting | Tel Aviv | Other | 6997801 | Israel |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| D000093763 | Intermittent Fasting |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| Time-restricted eating | Behavioral | All participants in TRE will perform supervised and monitored RT three time per week for the 10 weeks of intervention. Participants in the TRE group will be instructed to consume all meals between 12pm to 8pm, and to avoid consumption of food or caloric drinks during the fasting period (8 h eating window with 16 h of fasting). |
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Body composition assessment fat mass (kg) using DXA, BOD POD and BIA
| 10 weeks |
| D009750 |
| Nutritional and Metabolic Diseases |
| D005215 | Fasting |
| D005247 | Feeding Behavior |
| D001519 | Behavior |