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Prior studies have shown that programs that focus on promoting brain health and managing lifestyle risks (such as poor diet, obesity, physical inactivity, sleep issues, loneliness) may help in preventing or lowering the risk of dementia. To address this, investigators have developed the CAN-THUMBS UP program to conduct studies that target lifestyle risk and focus on dementia prevention. An online Brain Health Support Program (BHSP) has been developed. The BHSP is an educational program designed to teach about dementia. Before the full BHSP is offered to a large group, we are conducting an initial pilot study to help assess the usability of the program.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No Dementia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Brain Health PRO | Behavioral | The BHSP is an educational program designed to teach about dementia. It aims to provide best available evidence for lifestyle changes that can help lower dementia risk, and to provide specific recommendations for positive lifestyle changes (e.g., physical exercises to try at home, healthy recipes). The program was developed as a collaborative effort by Canadian investigators who have expertise in the different areas of dementia prevention, along with input from older-adult citizen advisors. |
| Measure | Description | Time Frame |
|---|---|---|
| Functionality of the BHSP | Functionality of the web-based components of the BHSP measured in the pilot and qualitative focus group(s) questions | Nov 2021-Mar 2022 |
| User acceptance of the BHSP | User adherence and engagement using the online program during the pilot including dates and times of use, duration of use and completion of program assessments | Nov 2021-Mar 2022 |
| Usability of the BHSP | User satisfaction and evaluation of usability and acceptability of BHSP measured during the pilot and focus group(s) | Nov 2021-Mar 2022 |
| To assess participant satisfaction with the organization, presentation and personalization of the BHSP content | Qualitative evaluation of participant responses during the focus group discussion | Nov 2021-Mar 2022 |
| To evaluate the feasibility of remote data collection | User data, feedback and adherence to remote measures, such as: Screening evaluation by tele/video-conference, Neuropsychological Test Battery, Burst cognitive testing with the MyCogHealth app, online version of the Cogstate Brief Battery, Assessments of lifestyle risk factors (sleep, diet, mood, cognition, physical activity, vascular health, social and psychological health, vision and hearing), Actigraphy and EEG wearables as measures of total daily physical activity and sleep fragmentation, and Saliva sample collection for genomics testing (Polygenic Hazard Score) | Nov 2021-Mar 2022 |
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Inclusion Criteria:
Cognitively Intact (CI) Cognitively Intact plus Subjective Cognitive Impairment (CI + SCI) Mild Cognitive Impairment (MCI)
• AND Classified as being at increased risk of dementia based on at least one of the following: First-degree family history of dementia
Self-Reported or documented current and/or history at midlife (45-60) on any of the following risk factors:
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This study will recruit it's cohort from various locations around Canada.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of British Columbia | Vancouver | British Columbia | V6T 1Z4 | Canada | ||
| University of New Brunswick |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41278371 | Result | Philip G, Fiocco AJ, Belleville S, Chertkow H, Feldman HH, Montero-Odasso M, Nygaard HB, Savundranayagam MY; Canadian Consortium on Neurodegeneration in Aging (CCNA), CAN-THUMBS UP Study Group. Exploring the usability and perceived benefits of Brain Health PRO: An online educational program for healthy brain aging. Digit Health. 2025 Nov 19;11:20552076251395585. doi: 10.1177/20552076251395585. eCollection 2025 Jan-Dec. | |
| 40090784 |
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| ID | Term |
|---|---|
| D003704 | Dementia |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D019965 | Neurocognitive Disorders |
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|
|
| Fredericton |
| New Brunswick |
| E3B 5A3 |
| Canada |
| Baycrest | Toronto | Ontario | M6A 2E1 | Canada |
| Result |
| Belleville S, Anderson ND, Bherer L, Camicioli R, Carrier J, Chan S, Cuesta M, Dang-Vu TT, Dwosh E, Fiocco AJ, Ferland G, Gilbert B, Harris E, Itzhak I, Jarrett P, Kadri MA, Laurin D, Liu-Ambrose T, McGibbon CA, Middleton L, Miller L, Nygaard HB, Montero-Odasso M, Murphy K, Phillips N, Pichora-Fuller MK, Robillard JM, Smith EE, Speechley M, Trigui A, Wittich W, Chertkow H, Feldman HH; CTU expert group for the Canadian Consortium on Neurodegeneration in Aging (CCNA), CAN-THUMBS UP Study Group. Brain health PRO/Sante cerveau PRO: The development of a web-based program for dementia literacy and risk factor reduction. J Prev Alzheimers Dis. 2025 Jun;12(6):100134. doi: 10.1016/j.tjpad.2025.100134. Epub 2025 Mar 15. |
| D001523 | Mental Disorders |
| D003072 | Cognition Disorders |