A Study to Look at the Health Outcomes of Patients With COVID-19 and Influenza

Patient-Reported Outcomes Associated With COVID-19 and Influenza: A Prospective Survey Study on Outpatient Symptomatic Adults With Test-Confirmed Illness in the United States

The main purpose of this study is to understand:

• the symptoms of COVID-19 or influenza- health-related outcomes of people with COVID-19 or influenza (influenza only included in updated study analyses)
• the potential effects of COVID-19 vaccines in people with COVID-19

This study will enroll participants who are:

• 18 years or older
• reported to have symptoms with tests that have confirmed illness. The tests can be taken at any of CVS pharmacy COVID-19 or influenza test sites.

The study will collect vaccine history information from participants who are ready to take part in the study. Participant will be emailed a form with questions about their health related to COVID-19 or influenza during multiple follow-ups over a 6-month period.

This is a prospective non-interventional longitudinal cohort survey study. Repeated measures on PROs including: symptoms (prevalence, frequency, duration, and severity), EQ-5D-5L, and WPAI over 6 months will be collected and evaluated.

COVID-19 Cohort: Participants 18 years or older with test-confirmed COVID-19 illness and at least one patient-reported symptom.

Influenza Cohort: Participants 18 years or older with test-confirmed influenza illness and at least one patient-reported symptom.

All study objectives and outcomes will be assessed separately for the two study cohorts. Influenza cohort is only included in updated study analyses.

Inclusion Criteria:

• Age 18 or older
• Self-reported at least one symptom in the CVS Health pre-test screening questionnaire
• Positive result reported from diagnostic test for COVID-19 (or influenza in updated analysis)
• Evidence of a signed and dated informed consent through electronic consent process indicating that the participant has been informed of all pertinent aspects of the study
• Able to complete the questionnaires by themselves in English or Spanish

Exclusion Criteria:

- No symptoms reported in the study screening questionnaire