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Many patients develop autoimmune diseases after covid-19 vaccination, whether related to the vaccination or not, is still under study. This study will describe potential flare of ARD after COVID-19 vaccination, whether it leads to activity or new MSK manifestations development.
-In this study: patients with known diagnosed rheumatic diseases who are vaccinated (one or full doses) of any type of COVID-19 vaccines will be enrolled. new ARD and prevalence of different MSK manifestations after covid-19 vaccinations also will be reported. The prevalence of flare of ARD after covid-19 vaccinations will be dteremined. Also we will compare between different types and doses of covid-19 vaccinations in inducing ARD or flares.
Study Design: Cross sectional study Target population: any patient with pre-existing received any vaccination against covid-19 visiting rheumatology outpatient clinic.
-any patient develops MSK manifestations after covid-19 vaccination. The disease activity sataus will be measured according to the type of rheumatic disease. For RA , disease activity score28 will be used, in lupus: SLEDAI, in Behcet : BDCAF, in SpA: BASDAI.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| COVID-19 vaccination | Biological | different types of covid-19 vaccinations. |
| Measure | Description | Time Frame |
|---|---|---|
| -Prevalence of new ARD after covid-19 vaccinations | any ARD | 3 moths |
| prevalence of flare of ARD after covid-19 vaccinations | flare of any manifestations of the disease | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of non-specific MSK symptoms after Covid-19 vaccine. | any MSK symptoms | 3 months |
| Correlation of the MSK to the 1st and 2nd Covid vaccine dose | Correlation of the MSK to the 1st and 2nd Covid vaccine dose |
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Inclusion Criteria:
Age above 18 years Vaccinated against covid-19 (one dose or fully vaccinated)
Exclusion Criteria:
Receiving other vaccine e.g influenza Less than 18 years old
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Eligibility Criteria:
Patients above 18 years old having MRD manifestations vaccinated against covid-19.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mervat Eissa, MD | Contact | +201221738939 | metvateissa@kasralainy.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Mohamed Abuzaid, MD | Tanta University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kasr Alainy Hospital | Recruiting | Cairo | 15561 | Egypt |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D007239 | Infections |
| D012216 | Rheumatic Diseases |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D014777 | Virus Diseases |
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| ID | Term |
|---|---|
| C000719707 | heterologous prime boost COVID-19 vaccination |
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| 3 months |
| comparison between different type of covid-19 vaccine in inducing ARD or flare up. | any type of flare | 3 months |
| disease activity status in the patients who developed the ARD symptoms before and after the vaccine. | activity assessed by disease activity scores | 3 months |
| Any correlation between the appearance of MSK symptoms and the patient's medications | current medications | 3 months |
| D018352 |
| Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D009140 | Musculoskeletal Diseases |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |