Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Precise identification of the atrial fibrosis is essential for successful catheter ablation of atrial arrhythmias in patients with atrial fibrillation. Voltage mapping of endocardial electrograms is currently used to delineate the anatomical substrate, but this is influenced by the direction of the activation wave front and is limited by the patient-specific thresholds. Mapping of local myocardial electrical impedance may overcome these limitations.
Clinical series: Patients with atrial arrythmias undergoing catheter ablation of these will be submitted to mapping of both voltage and tissue impedance. Likewise, the accuracy of the two maps identifying the extent of the substrate will be assesssed by gadolinium imaging. The impedance system is already constructed and certified for clinical research use.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients with atrial arrhythmias undergoing catheter ablation of these | Patients will be submitted to mapping of both voltage and tissue impedance. The accuracy of the two maps identifying the extent and transmurality of the infarction will be assesssed by gadolinium imaging. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cardioz mapping | Device | Patients will be submitted to mapping of both voltage and tissue impedance. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparative detection of atrial scar by voltage mapping | Voltage will be measured at different sites of the atrial scar and healthy tissue. | 30 minutes |
| Comparative detection of atrial scar by impedance mapping | Myocardial local impedance spectroscopy will be measured at different sites of the atrial scar and healthy tissue. | 30 minutes |
| Comparative detection of atrial scar by gadolinium enhanced MR imaging | Intensity of gadolinium will be measured at different sites of the infarct scar and healthy tissue | 30 minutes |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Patients with atrial arrhythmias undergoing catheter ablation
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jose M Guerra, MD, PhD | Contact | +34935537058 | jguerra@santpau.cat | |
| Gerard Amorós, MSc, PhD | Contact | gamorosf@santpau.cat |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital de la Santa Creu i Sant Pau | Recruiting | Barcelona | 08026 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27630580 | Result | Amoros-Figueras G, Jorge E, Garcia-Sanchez T, Bragos R, Rosell-Ferrer J, Cinca J. Recognition of Fibrotic Infarct Density by the Pattern of Local Systolic-Diastolic Myocardial Electrical Impedance. Front Physiol. 2016 Aug 31;7:389. doi: 10.3389/fphys.2016.00389. eCollection 2016. | |
| 29197656 | Result | Amoros-Figueras G, Jorge E, Alonso-Martin C, Traver D, Ballesta M, Bragos R, Rosell-Ferrer J, Cinca J. Endocardial infarct scar recognition by myocardial electrical impedance is not influenced by changes in cardiac activation sequence. Heart Rhythm. 2018 Apr;15(4):589-596. doi: 10.1016/j.hrthm.2017.11.031. Epub 2017 Dec 27. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
Not provided
Not provided
Not provided
Not provided
Not provided
| 26608340 | Result | Jorge E, Amoros-Figueras G, Garcia-Sanchez T, Bragos R, Rosell-Ferrer J, Cinca J. Early detection of acute transmural myocardial ischemia by the phasic systolic-diastolic changes of local tissue electrical impedance. Am J Physiol Heart Circ Physiol. 2016 Feb 1;310(3):H436-43. doi: 10.1152/ajpheart.00754.2015. Epub 2015 Nov 25. |
| 41126919 | Derived | Amoros-Figueras G, Moreno-Weidmann Z, Mendez-Zurita F, Soriano-Amores M, Bragos R, Rosell-Ferrer J, Guerra JM. Local multifrequency impedance changes after radiofrequency ablation in human atria: potential use for tissue characterization. Front Cardiovasc Med. 2025 Oct 7;12:1668533. doi: 10.3389/fcvm.2025.1668533. eCollection 2025. |
| D013568 |
| Pathological Conditions, Signs and Symptoms |