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The goal of the Dortmund Vital Study is to validate previous hypotheses and to generate and validate new hypotheses about the relationship of ageing, working conditions, genetic makeup, stress, metabolic functions, cardiovascular system, immune system, and mental performance over the lifespan with a focus on healthy working adults. The Dortmund Vital Study is a multidisciplinary longitudinal study involving the Departments of Ergonomics, Immunology, Psychology and Neurosciences, and Toxicology of the Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo) in Dortmund, Germany, as well as several national and international cooperation partners.
The Dortmund Vital Study is designed as a combined cross-sectional and longitudinal study. About 600 subjects aged between 20 and 70 years will participate. A wide range of demographic, psychological, behavioral, sensory, cardiovascular, biochemical, immunological and biochemical data, a comprehensive EEG-based cognitive test battery as well as structural and functional magnetic resonance imaging (MRI) have been included in the study. Specifically, parameters obtained by MRI and EEG-related measures can be evaluated as a function of polygenic scores, metabolic products, concentration of immune cells, immune age and infections, such as Toxoplasmosis or COVID-19 that are largely unexplored. The same is true for environmental and lifestyle factors that impact on brain activity and behavior.
The initial testing has been conducted between 2016 and 2021 and will be repeated every five years (three follow-up measures until 2035).
The study will shed light on sources of large inter-individual differences in cognitive functioning with increasing age and reveal biological and lifestyle markers contributing to work ability, longevity and healthy aging on the one hand, and on risk factors for cognitive decline, mild cognitive impairment or even dementia on the other.
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| Measure | Description | Time Frame |
|---|---|---|
| Change in performance on global cognitive composite score assessed by neuropsychological tests | Change in performance on global cognitive composite score based on measures from neuropsychological tests: Digit-Span forward and backward, semantic memory in written and spoken versions (Word-Fluency), selective attention and attentional endurance (D2-R), crystallized intelligence (Multiple Choice Vocabulary Test), general cognitive status (Mini-Mental-State-Examination; MMSE), different aspects of verbal memory like learning performance and retrieval (Verbal Learning and Memory Tests; VLMT), psychomotor performance and speed of processing (Digit-Symbol-Test), interference control and inhibition (Stroop Test), task switching (Trail-Making-Test; TMT-A and TMT-B), two subtests from the performance testing system measuring logical reasoning and spatial rotation, and fluid intelligence assessed by Raven's Progressive Matrices. | Baseline and 5, 10, 15 years |
| Change in attentional performance and perceptual control as assessed by a computerized Bar Task | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in attentional performance and perceptual control assessed by the Bar Task. | Baseline and 5, 10, 15 years |
| Change in vigilance control as assessed by a computerized Psychomotor Vigilance Test | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in a Psychomotor Vigilance Test. | Baseline and 5, 10, 15 years |
| Change in stimulus-response compatibility and conflict processing assessed by the computerized Simon Task | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Simon task. | Baseline and 5, 10, 15 years |
| Change in updating and strategy learning assessed by the computerized AX-CPT Task |
| Measure | Description | Time Frame |
|---|---|---|
| Change in resting state EEG activity | Change in resting state EEG activity measured for 2 minutes with eyes open, and 2 minutes with eyes closed. | baseline and 5, 10, 15 years |
| Change in brain function MRI |
| Measure | Description | Time Frame |
|---|---|---|
| Genetic parameters (Single Nucleotide Polymorphisms; SNP) | A number of genetic polymorphisms coding common homozygotes, heterozygotes and rare homozygotes variants were selected which are potentially related to structure and function of the central nervous system. Blood samples were used for the DNA-genotyping of: Apo-E2, E3, E4 (rs7412, rs429358), BDNF Val66Met (rs6265), COMT-1 (rs4633), COMT-2 Val158Met (rs4680), DRD2 (rs6277, DRD1-48A/G (rs4532), CHRNA6-1 (rs1072003), CHRNA6-3 (rs2304297), CHRNB3-1 (rs13280604), CHRNB3-2 (rs4950), GPCPD1 (EDI3) (rs)6116869), GRIN2A (rs1969060), GRIN2A (rs8057394), GRIN2B (rs890), IL-1beta (rs16944), IL-6 (rs1800795), IL-12A (rs568408), TNF-alpha (rs1800629). |
Inclusion Criteria:
Exclusion Criteria:
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Healthy individuals from the general population.
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| Name | Affiliation | Role |
|---|---|---|
| Edmund Wascher, PhD | Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo) | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Technical University of Dortmund, Leibniz Research Centre for Working Environment and Human Factors | Dortmund | 44139 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35285810 | Background | Gajewski PD, Getzmann S, Brode P, Burke M, Cadenas C, Capellino S, Claus M, Genc E, Golka K, Hengstler JG, Kleinsorge T, Marchan R, Nitsche MA, Reinders J, van Thriel C, Watzl C, Wascher E. Impact of Biological and Lifestyle Factors on Cognitive Aging and Work Ability in the Dortmund Vital Study: Protocol of an Interdisciplinary, Cross-sectional, and Longitudinal Study. JMIR Res Protoc. 2022 Mar 14;11(3):e32352. doi: 10.2196/32352. | |
| 37861818 |
| Label | URL |
|---|---|
| This is the oficial site of the Dortmund Vital Study | View source |
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After primary analyses and publication of the main results the data and the scripts used for data analyses will be made available in repositories for secondary analyses. The transfer agreement will be prepared by the coordinators of the Dortmund Vital Study in consultation with the IfADo Research Data Management Unit.
After primary analyses and publication of the main results.
In order to access the data, scientists from IfADo, as well as external cooperation partners who plan to analyze data from the Dortmund Vital Study fill in a proposal form that includes a short description of the project and the respective hypotheses, the responsible persons, cooperation partners, data usage and analysis strategy. The requested research data will be made available in an anonymized form after consultation with the scientists responsible for the data. Responsible persons include project managers and coordinators of the Dortmund Vital Study in consultation with the IfADo Research Data Management Unit.
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| ID | Term |
|---|---|
| D003141 | Communicable Diseases |
| ID | Term |
|---|---|
| D007239 | Infections |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Peripheral venous blood, serum, urine, hair samples
Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the AX-CPT task.
| Baseline and 5, 10, 15 years |
| Change in speech understanding and auditory distractibility assessed by computerized Speech-In-Noise perception task | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Speech-in-noise perception task. | Baseline and 5, 10, 15 years |
| Change in working memory assessed by the computerized N-back Task | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the N-back task. | Baseline and 5, 10, 15 years |
| Change in cue and memory-based task switching assessed by the computerized Task Switching Paradigm | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the cue- and memory based task switching. | Baseline and 5, 10, 15 years |
| Change in auditive attention and distractibility assessed by the computerized Auditory Distraction Task | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Auditory Distraction Task. | Baseline and 5, 10, 15 years |
| Change in susceptibility to interference and the capacity to inhibit irrelevant stimuli assessed by the computerized Stroop Task | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Stroop Task. | Baseline and 5, 10, 15 years |
| Change in inhibitory control of prepotent responses assessed by the computerized Go/NoGo Task | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Go/NoGo Task. | Baseline and 5, 10, 15 years |
| Change in spatial selective attention assessed by the computerized Visual Search Task | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Visual Search Task. | Baseline and 5, 10, 15 years |
| Change in Work Ability Index | Change in work ability assessed by Work Ability Index (WAI). WAI assess physical and psychological risks to avoid work-related disabilities and early retirement. The index is determined by the employees' answers related to work demands, individual health status and physical and psychological capacities. The total score of WAI is calculated by summing up scores of seven dimensions. The work ability ranged between 7 (insufficient) and 49 points (best work ability). | Baseline and 5, 10, 15 years |
Changes in functional magnetic resonance imaging assessed by resting state MRI.
| 5, 10, 15 years |
| Change in brain structure MRI | Changes in structural resonance imaging assessed by multi-shell diffusion-weighted imaging (DWI). | 5, 10, 15 years |
| Change in Depressive Symptoms | Change in total score using the Becks Depression Inventory (BDI). | Baseline and 5, 10, 15 years |
| Change in Burnout Symptoms | Change in total score using the Maslach Burnout Inventory (MBI-D) with 6-point Likert-type scale ranging from 1 (never) to 6 (always), total scores: 14 - 84. Higher scores indicate more severe symptoms. | Baseline and 5, 10, 15 years |
| Change in Burnout Symptoms | Change in total score using the Oldenburg Burnout Inventory (OLBI). 4-point Likert-type scale ranging from 1 (strongly agree) to 4 (strongly disagree), total scores: 8 - 32. Higher scores indicate more severe symptoms. | Baseline and 5, 10, 15 years |
| Change in Psychosocial Stress Symptoms | Change in total score using the Psychosocial Stress Questionnaire (PSQ-20). | Baseline and 5, 10, 15 years |
| Change in Chronic Stress Symptoms | Change in chronic stress symptoms assessed by the Trier Inventory of Chronic Stress (TICS), consisting of several dimensions: Work Overload, Social Overload, Pressure to Perform, Work Discontent, Demands from work, Lack of Social Recognition, Social Tensions, Social Isolation, Chronic Worrying, and a 12 Item Screening-Scale (SSCS) that provides a score for general stress. | Baseline and 5, 10, 15 years |
| Change in Psychosocial Work Demands | Change in total score in the Copenhagen Psychosocial Questionnaire (COPSOQ III) that consists of several dimensions: cognitive and physical demands at work, job control, influence at work, developmental possibilities, interpersonal relations, leadership, and strain. | 5, 10, 15 years |
| Change in Self-Control at work | Change of the psychosocial demands at work assessed by the scale Self-Control at Work. | Baseline and 5, 10, 15 years |
| Change in Cognitive Failures in the Daily Life | Change in cognitive failures in daily life assessed by the Cognitive Failure Questionnaire (CFQ). | Baseline and 5, 10, 15 years |
| Change in Positive and Negative Affect | Change in scores of positive and negative affect. The Positive and Negative Affect Schedule (PANAS) is a self-report questionnaire that consists of two 10-item scales to measure both positive and negative affect. | Baseline and 5, 10, 15 years |
| Change in Quality of Life | Change in total score of the quality of life questionnaire (WHOQoL-BREF), consisting of dimensions: physical, psychological, social, environmental, and global quality of life. | Baseline and 5, 10, 15 years |
| Change in sociodemographic parameters | Change in different sociodemographic aspects like marital status, occupational status, nutrition, leisure activities, alcohol drinking, frequency of social contacts, using of electronic media etc. Qualitative data will be categorized. | Baseline and 5, 10, 15 years |
| Change in self-reported physical activity | Change of the self-reported physical activity (Lüdenscheid Physical Activity Questionnaire) in minutes per week. | Baseline and 5, 10, 15 years |
| Change in lateralization and motor functions | Change in total score of the Perdue Pegboard Test, assessing lateralization and motor functions. | Baseline and 5, 10, 15 years |
| Change of cytokines concentration in serum | Change of concentration of cytokines in serum (pg/ml): (IL-1b, IFN-alpha, IFN-gamma, TNF-alpha, MCP-1, IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-18, IL-23, IL-33). | Baseline and 5, 10, 15 years |
| Change of functional activiy of T cells and Natural Killer cells | Change of functional activities of T cells and natural killer cells in %. | Baseline and 5, 10, 15 years |
| Change of peripheral blood mononuclear cells concentration | Change of peripheral blood mononuclear cells concentration (pg/ml): (PBMC; CD14 positive monocytes). | Baseline and 5, 10, 15 years |
| Change in physical performance | Change of physical fitness assessed by bicycle ergometer and a physical work capacity cycle test (PWC-130) to predict the absolute power output (in Watt) at a projected heart rate of 130 beats per minute. A relative power output is calculated by the power-to-weight ratio (Watt/kg). | Baseline and 5, 10, 15 years |
| Change in cardiovascular parameters | Diastolic and systolic blood pressure (mm/Hg) and pulse (bpm) measured during rest and during cycle ergometry. | Baseline and 5, 10, 15 years |
| Change in electrocardiography | Change in electrocardiogram (ECG) measured during rest and during cycle ergometry. | Baseline and 5, 10, 15 years |
| Change in antibody concentrations of Toxoplasma gondii in serum | Change of concentration of Toxoplasma gondii IgG antibodies (pg/ml) in serum to assess the severity of latent toxoplasmosis infection. | Baseline and 5, 10, 15 years |
| Change in antibody concentrations of COVID-19 in serum | Concentration of COVID-19 antibodies (pg/ml) in serum to assess the intensity of immunological response to potential SARC-CoV-2 infection or response to vaccination. | 5, 10, 15 years |
| Change in metabolic parameters in blood | Change in metabolic parameters in serum (pg/ml): concentration of ammonia, leucocytes, erythrocytes, hematocrit, monocytes, creatinine, lymphocytes, cell volume, thrombocytes, triglycerides, cholesterol, high- and low-density lipoprotein cholesterol, glycosylated hemoglobin, glucose, C-reactive protein and creatinine are measured in venous blood. | Baseline and 5, 10, 15 years |
| Change of metabolic parameters in urine | Change in metabolic parameters in urine (pg/ml): concentartion of creatinine and calcium oxalate. | Baseline and 5, 10, 15 years |
| Change of endocrine parameter | Change of hair cortisol concentration (pg/mg) as an index of long-term stress. | Baseline and 5, 10, 15 years |
| Baseline |
| Change in visual acuity | Change in visual acuity assessed by Vistec's Optovist according to DIN 58220-3 "Visual acuity testing - Part 3: Test for use in expertise" for far vision with the right and left eye separately (monocular) and with both eyes together (binocular), and if available with correction for distance (glasses for far vision). The "inclined optometer" is used to determine the zones of sufficient vision binocular at horizontal gaze inclination. For this, the near and far points are obtained, if available with distance correction (glasses for far vision). | Baseline and 5, 10, 15 years |
| Change in auditory acuity | Change in auditory acuity evaluated by audiometry. Audiometric thresholds are tested for ten pure-tone frequencies (125, 250, 500, 750, 1000, 2000, 3000, 4000, 6000, 8000 Hz) for the left and right ears separately. | Baseline and 5, 10, 15 years |
| Change in Body Mass Index | Height (m) and weight (kg) are measured to compute the Body Mass Index (BMI in kg/m^2). | Baseline and 5, 10, 15 years |
| Change in Waist-To-Hip ratio | Waist- and hip measurements (cm) are measured to compute the waist-to-hip ratio. | Baseline and 5, 10, 15 years |
| Personality traits | Personality traits are evaluated by the Big-Five-Factor inventory (NEO-FFI), assessing the personality dimensions: neuroticism, extraversion, openness, agreeableness, and conscientiousness. Grit personality trait are assessed by the GRID scale and the self-control by the general self-control scale. | Baseline |
| Stress reactivity | Subjective stress reactivity are assessed by the Perceived Stress Reactivity Scale (PSRS). | Baseline |
| Chronotype | The chronotype assessing the morning or evening type is evaluated by (D-MEQ). | Baseline |
| Handedness | Handedness is evaluated by Handedness Edinburgh Inventory. | Baseline |
| Traumatic Experiences During Childhood | Traumatic experiences during childhood are assessed to evaluate stress reactivity in the adult life. | Baseline |
| Sociodemographic characteristics | Sociodemographic characteristics like education, history of physical activity, marital status, children etc. were obtained. Qualitative data are categorized. | Baseline |
| Experiences with COVID-19 pandemic | Questionnaire addressing COVID-19-specific experience with the pandemic and the consequences of a COVID-19 infection (if applicable). | 5, 10, 15 years |
| Result |
| Kleinert T, Nash K, Koenig T, Wascher E. Correction: Normative Intercorrelations between EEG Microstate Characteristics. Brain Topogr. 2024 Mar;37(2):270. doi: 10.1007/s10548-023-01012-4. No abstract available. |
| 37450085 | Result | Kleinert T, Nash K, Koenig T, Wascher E. Normative Intercorrelations Between EEG Microstate Characteristics. Brain Topogr. 2024 Mar;37(2):265-269. doi: 10.1007/s10548-023-00988-3. Epub 2023 Jul 14. |
| 37410275 | Result | Kleinert T, Koenig T, Nash K, Wascher E. On the Reliability of the EEG Microstate Approach. Brain Topogr. 2024 Mar;37(2):271-286. doi: 10.1007/s10548-023-00982-9. Epub 2023 Jul 6. |
| 39316947 | Result | Getzmann S, Arnau S, Gajewski PD, Wascher E. Auditory distraction, time perception, and the role of age: ERP evidence from a large cohort study. Neurobiol Aging. 2024 Dec;144:114-126. doi: 10.1016/j.neurobiolaging.2024.09.012. Epub 2024 Sep 20. |
| 39256413 | Result | Getzmann S, Gajewski PD, Schneider D, Wascher E. Resting-state EEG data before and after cognitive activity across the adult lifespan and a 5-year follow-up. Sci Data. 2024 Sep 10;11(1):988. doi: 10.1038/s41597-024-03797-w. |
| 38968414 | Result | Mundorf A, Getzmann S, Gajewski PD, Larra MF, Wascher E, Genc E, Ocklenburg S. Phenotyping in clinical laterality research: a comparison of commonly used methods to determine mixed-handedness and ambidexterity. Laterality. 2024 May;29(3):331-349. doi: 10.1080/1357650X.2024.2370871. Epub 2024 Jul 5. |
| 38759431 | Result | Larra MF, Gajewski PD, Getzmann S, Wascher E, Metzler Y. Stress from early life to adulthood: Is there a protective role of cognitive control? Brain Cogn. 2024 Aug;178:106165. doi: 10.1016/j.bandc.2024.106165. Epub 2024 May 16. |
| 38398703 | Result | Getzmann S, Golka K, Brode P, Reinders J, Kadhum T, Hengstler JG, Wascher E, Gajewski PD. Chronic Toxoplasma gondii Infection Modulates Hearing Ability across the Adult Life Span. Life (Basel). 2024 Jan 29;14(2):194. doi: 10.3390/life14020194. |
| 37685992 | Result | Brode P, Claus M, Gajewski PD, Getzmann S, Wascher E, Watzl C. From Immunosenescence to Aging Types-Establishing Reference Intervals for Immune Age Biomarkers by Centile Estimation. Int J Mol Sci. 2023 Aug 24;24(17):13186. doi: 10.3390/ijms241713186. |
| 37397318 | Result | Gajewski PD, Golka K, Hengstler JG, Kadhum T, Digutsch J, Genc E, Wascher E, Getzmann S. Does physical fitness affect cognitive functions differently across adulthood? An advantage of being older. Front Psychol. 2023 Jun 16;14:1134770. doi: 10.3389/fpsyg.2023.1134770. eCollection 2023. |
| 36525080 | Result | Rieker JA, Gajewski PD, Reales JM, Ballesteros S, Golka K, Hengstler JG, Wascher E, Getzmann S. The impact of physical fitness, social life, and cognitive functions on work ability in middle-aged and older adults. Int Arch Occup Environ Health. 2023 May;96(4):507-520. doi: 10.1007/s00420-022-01943-8. Epub 2022 Dec 16. |
| 36682499 | Result | Akan O, Bierbrauer A, Kunz L, Gajewski PD, Getzmann S, Hengstler JG, Wascher E, Axmacher N, Wolf OT. Chronic stress is associated with specific path integration deficits. Behav Brain Res. 2023 Mar 28;442:114305. doi: 10.1016/j.bbr.2023.114305. Epub 2023 Jan 20. |
| 34859527 | Result | Getzmann S, Arnau S, Gajewski PD, Wascher E. When long appears short: Effects of auditory distraction on event-related potential correlates of time perception. Eur J Neurosci. 2022 Jan;55(1):121-137. doi: 10.1111/ejn.15553. Epub 2021 Dec 14. |
| 36881943 | Result | Getzmann S, Schneider D, Wascher E. Selective spatial attention in lateralized multi-talker speech perception: EEG correlates and the role of age. Neurobiol Aging. 2023 Jun;126:1-13. doi: 10.1016/j.neurobiolaging.2023.02.003. Epub 2023 Feb 14. |
| 35675345 | Result | Wascher E, Sharifian F, Gutberlet M, Schneider D, Getzmann S, Arnau S. Mental chronometry in big noisy data. PLoS One. 2022 Jun 8;17(6):e0268916. doi: 10.1371/journal.pone.0268916. eCollection 2022. |
| 34216693 | Result | Sharifian F, Schneider D, Arnau S, Wascher E. Decoding of cognitive processes involved in the continuous performance task. Int J Psychophysiol. 2021 Sep;167:57-68. doi: 10.1016/j.ijpsycho.2021.06.012. Epub 2021 Jul 1. |
| 34682500 | Result | Getzmann S, Digutsch J, Kleinsorge T. COVID-19 Pandemic and Personality: Agreeable People Are More Stressed by the Feeling of Missing. Int J Environ Res Public Health. 2021 Oct 13;18(20):10759. doi: 10.3390/ijerph182010759. |
| 34676455 | Result | Metzen D, Genc E, Getzmann S, Larra MF, Wascher E, Ocklenburg S. Frontal and parietal EEG alpha asymmetry: a large-scale investigation of short-term reliability on distinct EEG systems. Brain Struct Funct. 2022 Mar;227(2):725-740. doi: 10.1007/s00429-021-02399-1. Epub 2021 Oct 21. |
| 32923622 | Result | Bierbrauer A, Kunz L, Gomes CA, Luhmann M, Deuker L, Getzmann S, Wascher E, Gajewski PD, Hengstler JG, Fernandez-Alvarez M, Atienza M, Cammisuli DM, Bonatti F, Pruneti C, Percesepe A, Bellaali Y, Hanseeuw B, Strange BA, Cantero JL, Axmacher N. Unmasking selective path integration deficits in Alzheimer's disease risk carriers. Sci Adv. 2020 Aug 28;6(35):eaba1394. doi: 10.1126/sciadv.aba1394. eCollection 2020 Aug. |
| 30534095 | Result | Gajewski PD, Hanisch E, Falkenstein M, Thones S, Wascher E. What Does the n-Back Task Measure as We Get Older? Relations Between Working-Memory Measures and Other Cognitive Functions Across the Lifespan. Front Psychol. 2018 Nov 26;9:2208. doi: 10.3389/fpsyg.2018.02208. eCollection 2018. |
| 36358277 | Result | Brode P, Claus M, Gajewski PD, Getzmann S, Golka K, Hengstler JG, Wascher E, Watzl C. Calibrating a Comprehensive Immune Age Metric to Analyze the Cross Sectional Age-Related Decline in Cardiorespiratory Fitness. Biology (Basel). 2022 Oct 27;11(11):1576. doi: 10.3390/biology11111576. |
| 37099727 | Result | Mundorf A, Getzmann S, Gajewski PD, Larra MF, Wascher E, Ocklenburg S. Stress exposure, hand preference, and hand skill: A deep phenotyping approach. Laterality. 2023 Mar-May;28(2-3):209-237. doi: 10.1080/1357650X.2023.2204551. Epub 2023 Apr 26. |
| 37204831 | Result | Gajewski PD, Rieker JA, Athanassiou G, Brode P, Claus M, Golka K, Hengstler JG, Kleinsorge T, Nitsche MA, Reinders J, Tisch A, Watzl C, Wascher E, Getzmann S. A Systematic Analysis of Biological, Sociodemographic, Psychosocial, and Lifestyle Factors Contributing to Work Ability Across the Working Life Span: Cross-sectional Study. JMIR Form Res. 2023 May 19;7:e40818. doi: 10.2196/40818. |
| 42243262 | Derived | Metzler YA, Schade HM, Nitsche MA, Wascher E, Getzmann S, Gajewski PD, Melo L. Beyond composite scores in chronotype assessment: item-level predictive patterns in the Morningness-Eveningness Questionnaire. Sci Rep. 2026 Jun 4;16(1):17347. doi: 10.1038/s41598-026-54301-w. |
| 41868967 | Derived | Jungeblut HM, Genc E, Burke M, Gajewski PD, Getzmann S, Wascher E, Schubert AL. The latent organization of white matter microstructure and its relation to fluid intelligence. Imaging Neurosci (Camb). 2026 Mar 19;4:IMAG.a.1167. doi: 10.1162/IMAG.a.1167. eCollection 2026. |
| 41738010 | Derived | Sabo M, Varlet M, Wascher E, Gajewski PD, Grootswagers T. Multiple partially overlapping neural modules orchestrate conflict processing. Imaging Neurosci (Camb). 2026 Feb 20;4:IMAG.a.1135. doi: 10.1162/IMAG.a.1135. eCollection 2026. |
| 41594595 | Derived | Brode P, Claus M, Getzmann S, Golka K, Hengstler JG, Reinders J, Wascher E, Watzl C, Gajewski PD. Latent Toxoplasma gondii Infection Does Not Modulate Immune Aging in a Cross-Sectional Working-Age Population Study. Biomolecules. 2025 Dec 30;16(1):55. doi: 10.3390/biom16010055. |
| 41272243 | Derived | Engler R, Stammen C, Arnau S, Schneider Penate J, Metzen D, Digutsch J, Gajewski PD, Getzmann S, Fraenz C, Reinders J, Voelkle MC, Streit F, Ocklenburg S, Schneider D, Burke M, Hengstler JG, Watzl C, Nitsche MA, Kumsta R, Wascher E, Genc E. Electrophysiological resting-state signatures link polygenic scores to general intelligence. Sci Rep. 2025 Nov 21;15(1):41170. doi: 10.1038/s41598-025-26778-4. |
| 41018675 | Derived | Gajewski PD, Brode P, Claus M, Golka K, Hengstler JG, Reinders J, Watzl C, Wascher E, Getzmann S. Changes of cognitive functions and proinflammatory cytokines across the lifespan in latent Toxoplasma gondii infection. Brain Behav Immun Health. 2025 Sep 15;49:101105. doi: 10.1016/j.bbih.2025.101105. eCollection 2025 Nov. |
| 39717874 | Derived | Gajewski PD, Brode P, Claus M, Golka K, Hengstler JG, Watzl C, Wascher E, Getzmann S. The association between hair cortisol and burnout is moderated by age, psychosocial, and immunological markers. Brain Behav Immun Health. 2024 Nov 23;43:100909. doi: 10.1016/j.bbih.2024.100909. eCollection 2025 Feb. |