HYBIS project aims to develop an innovative and unique hybrid Brain-Computer Interface (BCI) system. This BCI system is envisioned as a novel tool for targeted reinforcement of sensory motor coupling, specifically dedicated for upper-limb post-stroke rehabilitation.

Inclusion Criteria:

• age over 18 years old at the time of enrolment
• history of cerebrovascular insult verified by computerized tomography or magnetic resonance imaging;
• stoke occurred not more than 6 months prior to study enrolment;
• subject need to be medically and neurologically stable determined by medical history and documented neurological examination;
• ability to understand, communicate and cooperate with the research team;
• ability to sit for at least 45 minutes and the ability to adhere to the study rehabilitation protocol.

Exclusion Criteria:

• any neurologic condition (beyond the stroke) or physical condition that impaired function of the affected arm
• a substantial cardiopulmonary or metabolic disorder or other major medical complication;
• history of seizures;
• moderate to severe hemispatial neglect or anosognosia involving the affected arm;
• severe sensory deficit;
• inability to understand, cooperate, and adhere to the study procedures;
• severe spasticity defined as Ashworth scale score of 4 in the affected arm;
• contraindication to stimulation system placement;
• nursing a child;
• pregnancy.