Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Application of artificial intelligence deep learning algorithm to analyze the relationship between hormone sensitivity of idiopathic interstitial pneumonia and imaging features of high resolution CT.
Methods: the medical records and chest high-resolution CT images of patients with idiopathic interstitial pneumonia admitted to the respiratory department of the Third Hospital of Peking University from June 1, 2012 to December 31, 2020 were retrospectively analyzed.Application of artificial intelligence deep learning neural convolution network method to create recognition technology of different imaging features.Including ground glass, mesh, honeycomb, nodule or consolidation, the model was established. IIP patients were divided into hormone sensitive group and hormone insensitive group according to whether the use of hormone was effective or not.Logistic regression analysis was used to analyze the correlation between statistically significant parameters and hormone sensitivity.Artificial intelligence was used to establish the correlation model between imaging features and clinical data and hormone sensitivity.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hormone sensitive group | Prednisone, 0.5mg/kgqd, 3-6months |
| |
| Hormone insensitivity group | Prednisone, 0.5mg/kgqd, 3-6months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| high resolution CT | Radiation | Ground glass,honeycomb,reticulation, consolidation |
|
| Measure | Description | Time Frame |
|---|---|---|
| clinical data and imaging feature ratios in both groups | clinical data including ages,gender,symptoms,signs,smoking history,complications,laboratory examination,lung function. Imaging feature including ground-glass opacity, reticulation, honeycomb and consolidation. | 3-6 months after medication |
| Measure | Description | Time Frame |
|---|---|---|
| the relationship between imaging feature ratios and hormone sensibility | Logistic regression analyzing the relationship between imaging feature ratios and hormone sensibility. | 3-6 months after medication |
| Measure | Description | Time Frame |
|---|---|---|
| development of artificial intelligence algorithm model | The U-net method of deep learning convolutional neural network (CNN) was used to create the recognition model of different imaging features. Imaging features include ground-glass opacity, reticulation, honeycomb and consolidation. With the area ratio of imaging features of the two groups as the input and hormone efficacy as the output, the correlation model between imaging features and hormone sensitivity was established by using artificial intelligence k nearest neighbor (KNN) algorithm and support vector machine (SVM) algorithm. |
Inclusion Criteria:
Clinical-pathological-radiology diagnosis of idiopathic interstitial pneumonia Hormone therapy was used; The follow-up data were complete, and the effect of hormone use could be judged.
Exclusion Criteria:
Lung infection disease; Heart failure; Connective tissue disease; IIP Without hormone therapy ; IIP but the follow-up data were incomplete, and the effect of hormone use could not be judged.
Not provided
Not provided
From June 1, 2012 to December 31, 2020, all inpatients with IIP were admitted to the respiratory and critical care department of the Third Hospital of Peking University. Total patients are 150, 45 patients using hormone, average age 62 years old, 21 male.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Bei He | Peking University Third Hospital Respiratory and critical care department | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University Third Hospital | Beijing | Beijing Municipality | 100191 | China |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D054988 | Idiopathic Interstitial Pneumonias |
| ID | Term |
|---|---|
| D054990 | Idiopathic Pulmonary Fibrosis |
| D011658 | Pulmonary Fibrosis |
| D017563 | Lung Diseases, Interstitial |
| D008171 | Lung Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
| 3-6 months after medication |
| D012140 | Respiratory Tract Diseases |