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This is a prospective study that would investigate the transcranial doppler (TCD) changes during the living donor liver transplantation and the association between the TCD changes and the post-transplant neurological complications.
Objectives:
Participants & Setting:
Intervention & Measurements:
Sample size:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TCD arm | Experimental | All patients will be evaluated with TCD for prediction of the post-transplant neurological complications |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Doppler | Diagnostic Test | Transcranial Doppler-derived parameters; pulsatility index (PI), resistance index (RI), mean flow velocity (Vmean) will be recorded before induction of anesthesia (T1). After induction, TCD parameters, Hemodynamic variables including heart rate (HR), invasive mean arterial blood pressure (MAP), and central venous pressure (CVP) together with Arterial blood gases (ABG analysis with values of PH, PCO2, PO2, blood oxygen saturation SO2 and bicarbonate HCO3), end-tidal carbon dioxide (ETCO2) and body temperature will be recorded too. Just before skin incision (T2), at the end of anhepatic phase 5 minutes before reperfusion (T3), 5 minutes after reperfusion (T4) and at the end of surgery (T5). Postoperatively at ICU, TCD parameters, Hemodynamic variables, and ABG will be obtained 24 hours postoperative (T6) and at discharge from ICU (T7). |
| Measure | Description | Time Frame |
|---|---|---|
| Post-transplant Neurological Complication | incidence of Neurological Complication as a composite outcome (tremors, seizures, demyelination, posterior reversible encephalopathy syndrome, stroke) | 28 days after transplantation |
| Measure | Description | Time Frame |
|---|---|---|
| flow patterns throughout the transplant surgery and in the ICU | normal, hyperemic, low-flow, or vasospastic flow by TCD | intraoperative and 7 days after transplantion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Moataz M Emara, MD, EDAIC | Contact | +201064048848 | mm.emara@mans.edu.eg | |
| Kareem M Abozeid, MSc | Contact | 1557442411 | +20 | kareemmohabozeid27@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Amr M Yassen, MD | Mansoura University Faculty of Medicine | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mansoura University, Gastrointestinal Surgery Center, Liver Transplantation Unit | Recruiting | Al Mansurah | Dakahlia Governorate | 35516 | Egypt |
Data will be available with the corresponding author at reasonable request. The Data publishing with the manuscript will be discussed later.
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will be updated
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| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D009461 | Neurologic Manifestations |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D017585 | Ultrasonography, Doppler, Transcranial |
| ID | Term |
|---|---|
| D004453 | Echoencephalography |
| D009485 | Neuroradiography |
| D059906 | Neuroimaging |
| D003952 | Diagnostic Imaging |
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A single-arm trial involving 100 patients undergoing living donor liver transplantation; all will be examined using transcranial doppler to find out its predictive value on post-transplant neurological deficits.
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|
| D019937 |
| Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011859 | Radiography |
| D014463 | Ultrasonography |
| D018608 | Ultrasonography, Doppler |
| D003943 | Diagnostic Techniques, Neurological |
| D008919 | Investigative Techniques |