The study is being conducted to determine the dose limited toxicity(DLT) and maximum tolerated dose(MTD) and recommended Phase 2 dose(RP2D) of HRS2398 in subjects with advanced malignant tumor ; The second objectives is to evaluate safety and preliminary efficacy and PK profile of HRS2398 in subjects with advanced malignant tumor ; Exploratory cohort is to explore the relationship between gene mutation and efficacy and resistance mechanisms.

Inclusion Criteria:

1. Subjects are able to give voluntary informed consent, understand the study and are willing to follow and complete all the test procedures.

2. subjects ≥18 years and ≤70 years.

3. Patients with Histologically or cytologically confirmed advanced Malignant tumors who had failed standard treatment or had not been treated with standard therapy.

4. ECOG ≤1.

5. Subjects with life expectancy of ≥ 3 months.

6. At least one measurable lesion ( RECIST version 1.1).

7. Subjects must have adequate organ function (whole blood or component transfusion or BFGF within 2 weeks before 1st dose of study drug is prohibited):

   1. Absolute neutrophil count (ANC) ≥1.5 x10^9/L;
   2. Platelet count ≥ 100 x 10^9/L;
   3. Hemoglobin ≥ 90 g / L;
   4. Total bilirubin (TBil) ≤1.5 x ULN;
   5. Liver function tests alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤3 x ULN, for patients with known liver cancer or liver metastases, AST and ALT ≤ 5 x ULN;
   6. Gr ≤ 1.5x ULN or an estimated glomerular filtration rate (eGFR) > 50 mL/min;
   7. INR ≤1.5 x ULN and APTT ≤ 1.5 x ULN;
   8. LVEF≥50%，QTc Male: <450ms; Female: <470ms.

8. Subjects (males and females) of childbearing potential should be willing to use reliable contraception methods that are deemed effective by the investigator from visit 1 through 180 days following the last dose of study drug.

9. Archived wax lump tumor tissue samples or biopsy and blood sample collection during screening period.

10. As judged by the investigator, can follow protocol.

Exclusion Criteria:

1. Untreated and/or uncontrolled brain metastases.
2. Patients with clinical symptoms of cancer ascites, pleural effusion, who need to drainage, or who have undergone ascites drainage within 2 weeks prior to the first administration.
3. Failure to recover from adverse events from the most recent anti-tumor treatment to CTCAE ≤ grade2.
4. Inability to swallow tablets or gastrointestinal disease, possible impairment of adequate absorption of study drugs.
5. Have severe cardiac disease:NYHA class ≥grade II heart failure; unstable angina pectoris；myocardial infarction within 12 months； clinically significant supraventricular or ventricular arrhythmias require treatment or intervention; Hypertension that cannot be well controlled by antihypertensive medication (systolic blood pressure ≥150 mmHg or diastolic blood pressure ≥100 mmHg).
6. Known active hepatitis C virus, or known active hepatitis B virus.
7. Allergic to the HRS2398 or the similar drug.
8. Concurrent anticancer treatment or use of other investigational product within 4 weeks before start of trial treatment; major surgery, radiotherapy, chemotherapy within 4 weeks before 1st dose of trial treatment.
9. The patient is currently using a drug known to be a strong inhibitor of CYP3A4 within 2 weeks before 1st dose of study drug ，or strong inducer of CYP3A4 within 4 weeks before 1st dose of study drug .
10. The investigator determined that the patient should not participate in the study.