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This study aims at identifying the neurohormonal biomarkers that characterize individuals at risk of greater metabolic adaptation to weight loss, a disproportionate decline in resting metabolic rate during and after weight loss.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| lifestyle intervention | Experimental | Participants will be enrolled in a weight loss program based on lifestyle changes. They will be given a 6-month subscription to a calorie-reduced meal replacement program that also offers lifestyle coaching. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lifestyle intervention with meal replacement program | Other | participants will be enrolled in a medical weight loss program and will be given a 6 month subscription to a calorie-reduced meal replacement program, in addition to lifestyle advice. |
| Measure | Description | Time Frame |
|---|---|---|
| change in measured and predicted resting metabolic rate during and after weight loss | resting metabolic rate will be measured by indirect calorimetry every 2 months for 6 months, then every 6 months for an additional 12 month. Predicted resting metabolic rate will be calculated with a mathematical formula at the same time points | 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| change in circulating leptin during and after weight loss | blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months | 18 months |
| change in circulating thyroid hormones during and after weight loss |
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Inclusion Criteria:
BMI > or = 30 any ethnicity
Exclusion Criteria:
weight > or = 400 lbs.
diabetes (type 2 or type 1)
hypertension
heart disease
kidney disease
liver disease
active cancer
post solid organ or bone marrow transplant
HIV/AIDS
pregnancy
breastfeeding
current smoker
current recreational drug use
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| Name | Affiliation | Role |
|---|---|---|
| Lisa L Morselli, MD PhD | Medical College of Wisconsin | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | United States |
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| ID | Term |
|---|---|
| D015431 | Weight Loss |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D001836 | Body Weight Changes |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months |
| 18 months |
| change in circulating GLP-1 during and after weight loss | blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months | 18 months |
| change in circulating PYY during and after weight loss | blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months | 18 months |
| change in circulating AgRP during and after weight loss | blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months | 18 months |
| change in 24h urine catecholamines during and after weight loss | urine will be assayed for these hormones every 2 months for 6 months, then every 6 months for an additional 12 months | 18 months |
| change in heart rate variability during and after weight loss | blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months | 18 months |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |