1. Observe the influence of entering hemodialysis treatment on the emotional and cognitive functions of ESRD patients.
2. Observe the influence of entering hemodialysis treatment on the brain structure imaging of ESRD patients.
3. Analyze and study the relevant clinical risk factors of the above-mentioned effects, and find targets for therapeutic intervention.

Select uremic patients and maintenance hemodialysis patients admitted to the Central Dialysis Room of Beijing Friendship Hospital, Capital Medical University from 2021, to collect and sort out the demographic characteristics of the patients: gender, age, clinical characteristics: primary disease, complications and Complications, body mass index (BMI), residual renal function, etc., clinical examination indicators: hemoglobin, blood calcium, blood phosphorus, blood PTH, blood albumin, URR, etc., hemodialysis treatment parameters: dialysis mode, dialyzer model, vascular access , Blood flow, etc., record the patient's emotional and cognitive function status, various clinical indicators and changes in the patient's quality of life before and after the start of treatment, and use multimodal magnetic resonance neuroimaging research sequences to analyze the changes in the patient's brain structure and function.

Inclusion Criteria:

• Patients who are new to hemodialysis treatment, and those who are on regular hemodialysis treatment for ≥6 months.
• Age ≥ 18 years old.

Exclusion Criteria:

• There was already a severe central nervous system disease before dialysis.
• Hearing and visual impairment cannot communicate or cooperate.
• Mental illness and incapacity.
• The magnetic resonance examination could not be completed for various reasons.
• Life expectancy with serious diseases is less than 6 months.

Uremia patients undergoing hemodialysis treatment in the hemodialysis room of Beijing Friendship Hospital