Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to evaluate the risk factors of recurrent preeclampsia and compare the short-term and long-term adverse outcomes of women and their offspring.
The investigators collected women delivered twice in a row in our hospital. The investigators divided these pregnant women into three groups. Women in the first group did not complicate preeclampsia at both deliveries; Women in the second group complicated preeclampsia at the first delivery or at the second delivery; women in the third group complicated preeclampsia at two deliveries. The investigators explore the risk factors of recurrent preeclampsia and measure blood pressure, blood lipids, thyroid function, glycosylated hemoglobin, ALT, AST, et al. in one year, three years, and five years after the second delivery.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control | pregnancy without preeclampsia |
| |
| preeclampsia | pregnancy complicated with preeclampsia at the first delivery or at the second delivery |
| |
| recurrent preeclampsia | pregnancy complicated with preeclampsia at two deliveries |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood pressure,BMI, blood sample | Other | Blood pressure will be monitored. BMI will be measured. Blood samples will be tested. |
|
| Measure | Description | Time Frame |
|---|---|---|
| blood pressure and hypertension of women | blood pressure ≥140/90 mmHg | 1year after the second deliver |
| blood pressure and hypertension of women | blood pressure ≥140/90 mmHg | 3 years after the second deliver |
| blood pressure and hypertension of women | blood pressure ≥140/90 mmHg | 5 years after the second deliver |
| blood pressure and hypertension of offspring | blood pressure≥140/90 mmHg | 1 year old |
| blood pressure and hypertension of offspring | blood pressure≥140/90 mmHg | 3 years old |
| blood pressure and hypertension of offspring | blood pressure≥140/90 mmHg | 5 years old |
| level of glycosylated hemoglobin in blood | women | 1 year after the second deliver |
| level of glycosylated hemoglobin in blood | women | 3 years after the second deliver |
| level of glycosylated hemoglobin in blood |
| Measure | Description | Time Frame |
|---|---|---|
| BMI of offspring | weight(kg)/height(m)2 | 1 year old |
| BMI of offspring | weight(kg)/height(m)2 | 3 years old |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
women with at least twice of delivery history are divided into three groups, control group refers to women without preeclampsia history, the second group refers to women complicated with preeclampsia at the first delivery or at the second delivery, the third group refers to women complicated with preeclampsia at two deliveries.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dunjin Chen | Contact | 18928916722 | gzdrchen@gzhmu.edu.cn |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University | Guangzhou | 510150 | China |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| D012008 | Recurrence |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
Not provided
Not provided
Not provided
Not provided
Not provided
blood
women |
| 5 years after the second deliver |
| level of cholesterol, LDL, HDL, VLDL-C in blood | women | 1 year after the second deliver |
| level of cholesterol, LDL, HDL, VLDL-C in blood | women | 3 years after the second deliver |
| level of cholesterol, LDL, HDL, VLDL-C in blood | women | 5 years after the second deliver |
| level of FT3,FT4, and hTSH in blood | women | 1year after the second deliver |
| level of FT3,FT4, and hTSH in blood | women | 3 years after the second deliver |
| level of FT3,FT4, and hTSH in blood | women | 5 years after the second deliver |
| level of AST and ALT in blood | women | 1year after the second deliver |
| level of AST and ALT in blood | women | 3 years after the second deliver |
| level of AST and ALT in blood | women | 5 years after the second deliver |
| BMI of offspring | weight(kg)/height(m)2 | 5 years old |
| level of insulin in blood | women | 1year after the second deliver |
| level of insulin in blood | women | 3 years after the second deliver |
| level of insulin in blood | women | 5 years after the second deliver |
| level of fructosamine in blood | women | 1year after the second deliver |
| level of fructosamine in blood | women | 3 years after the second deliver |
| level of fructosamine in blood | women | 5 years after the second deliver |
| level of AI37℃、AI4℃、PRA、ALD、AngII in blood | women | 1 year after the second deliver |
| level of AI37℃、AI4℃、PRA、ALD、AngII in blood | women | 3 years after the second deliver |
| level of AI37℃、AI4℃、PRA、ALD、AngII in blood | women | 5 years after the second deliver |
|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |