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To improve the outcome of LIFT, some authors used a combined approach of LIFT. Pooled analysis of seven studies including 192 patients revealed a success rate of 83.5 % after combined LIFT approach. The use of bone marrow aspirate concentrate (BMAC) in surgery is not entirely new as it has been widely used in the treatment of bone defects, mandibular reconstruction, maxillary sinus augmentation and in critical limb ischemia.
A previous study concluded that the use of BMAC to augment external anal sphincter repair strengthens wound healing by transferring cells responsible for healing directly to the site of repair. The current study aimed to assess the outcome of local injection of bone marrow mononuclear cells (BM-MNCs) in conjunction with LIFT as compared to LIFT alone in regards to healing rate, time to healing, and ultimate success rate.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LIFT | Active Comparator | Patients underwent LIFT proecdure |
|
| LIFT+bone marrow mononuclear cell injection | Active Comparator | Patients underwent LIFT with bone marrow mononuclear cell injection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| bone marrow mononuclear cell injection | Procedure | bone marrow mononuclear cells were injected in the intersphincteric space and around the internal opening after ligation and division of the tract |
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with complete healing of anal fistula as assessed by clinical examination | Healing is defined as complete epithelization of the anal wound with absence of fistula tract | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mansoura university hospital | Al Mansurah | Dakahlia Governorate | 35516 | Egypt |
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| ID | Term |
|---|---|
| D012003 | Rectal Fistula |
| ID | Term |
|---|---|
| D007412 | Intestinal Fistula |
| D016154 | Digestive System Fistula |
| D004066 | Digestive System Diseases |
| D007410 | Intestinal Diseases |
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| LIFT | Procedure | The fistula tract is ligated in the intersphincteric space |
|
| D005767 | Gastrointestinal Diseases |
| D012002 | Rectal Diseases |
| D005402 | Fistula |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |