The purpose of this study is to investigate the ability of a wearable bioimpedance sensor to detect mild dehydration in healthy volunteers following the administration of Furosemide. In addition, the study will investigate changes in bioimpedance related to normal variation in tissue hydration (circadian changes, skin thickness, posture, and moderate activity). The study will also provide information on the durability of the sensor.

The subjects will use the patches for ten days. During the ten-day period, subjects are exposed to an intervention on day 2 or 3 while being monitored by health personnel:

• Subjects are given a diuretic (Furosemide) and monitored for two hours without any intake.
• The intervention is followed by intake of a rehydration solution (up to 1500 ml), containing glucose and electrolytes (Resorb Sport, Nestle S.A.).

Inclusion Criteria:

• BMI: 18-30
• Age: 18-60
• Willing to refrain from exercise for the duration of the study
• Willing to refrain from bathing, swimming and other physical activity causing considerable sweating/movement (e.g. cycling, mountain hiking, climbing)

Exclusion Criteria:

• Hypersensitivity to diuretics
• Diarrhea
• Hypotension or orthostatic hypotension
• Urinary retention
• Pregnancy or breast feeding
• Allergy to medical adhesive or gel
• Any planned medical examination during the intervention period
• Pacemaker
• Use of medication with a significant impact on the body's fluid balance, such as diuretic

No sharing planned. Application to ethical board does not include permission to share.