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The Coronavirus Pediatric Serological Study's aim is to provide a better insight of children's immune response after SARS-CoV-2 infection.
Serological tests were conducted on blood samples taken 3 to 5 months after the children's viral infection.
The study was performed in collaboration with the Institute of Medical Immunology, were antibody levels were measured and immunoglobulin subclasses profiles were studied.
The hospital laboratory provided us the list of children under 15 years old tested for SARS-CoV-2 in Saint-Pierre Hospital (Brussels) by PCR on nasopharyngeal swab between March 1 2020 and December 31 2020.
The medical files of all children that were tested positive for SARS-CoV-2 were reviewed and clinical information was collected.
For each positive child, the family was contacted by phone 3 months after the proven viral infection in order to ask permission to take a single blood test.
Covid19 serologies were performed in the hospital laboratory, and blood samples were then sent to the Institute of Medical Immunology, were antibody levels and immunoglobulin subclasses were studied.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Positive Children | Children under 15 years old tested positive for SARS-CoV-2 by PCR on nasopharyngeal swab |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sample | Diagnostic Test | Blood sample taken 3 to 5 months after the infection |
|
| Measure | Description | Time Frame |
|---|---|---|
| SARS-CoV-2 antibody levels in asymptomatic patients | Measurement of SARS-CoV-2 IgG (total and subclasses), IgA (total and subclasses) and IgM levels in the sera of children who did not show any symptoms at the time of the viral infection | 3 to 5 months after SARS-CoV-2 infection |
| SARS-CoV-2 antibody levels in mildly symptomatic patients | Measurement of SARS-CoV-2 IgG (total and subclasses), IgA (total and subclasses) and IgM levels in the sera of children presenting mild symptoms at the time of the viral infection | 3 to 5 months after SARS-CoV-2 infection |
| SARS-CoV-2 antibody levels in hospitalized patients | Measurement of SARS-CoV-2 IgG (total and subclasses), IgA (total and subclasses) and IgM levels in the sera of children who required an hospitalisation at the time of the viral infection | 3 to 5 months after SARS-CoV-2 infection |
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Inclusion Criteria:
- Tested positive for SARS-CoV-2 by PCR on naso-pharyngeal swab performed in Saint-Pierre Hospital (Brussels) between March 1 2020 and December 31 2020
Exclusion Criteria:
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Children under 15 years old
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Saint-Pierre Hospital | Brussels | 1000 | Belgium |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Blood samples
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |