Validity and Reliability of VO2-max Measurements in Persons With Parkinson's Disease

Validity and Reliability of VO2-max Measurements in Persons With Parkinson's Disease

Each participant would complete four test days and each test day is separated by 7-10 days. At each test day the participants would complete a graded maximal exercise test (VO2max-test), a chair rise (Linear encoder) as well as measuring of basic demographic outcomes (weight, fat%,blood pressure etc.). The first test day would further include a motor (MDS-UPDRS III) and cognitive examination (MoCA), a questionnaire about quality of life (PDQ-39) and one about depression (BDI-II). Furthermore, the first test day would include two test of walking performance (6 minutes walk test and Time Up and Go). Two of the test days would be completed while the participants are off their Parkinson disease medication for at least 12 hours, while the other two test days would be completed while on their Parkinson medication. The order of the tests would be randomized. It is hypothesized that the VO2max test would be reliable and valid when participants are on medication, while off-medication would affect the reliability and validity.

Inclusion Criteria:

• Age ≥ 40 year
• Written informed consent
• Diagnosed with idiopathic Parkinson's disease
• Hoehn & Yahr ≤ 3
• Taking dopaminergic medication
• Able to complete a maximal aerobic test on a bicycle

Exclusion Criteria:

• Dementia
• Alcohol abuse
• Pacemaker
• Serious cardiovascular, respiratory, orthopedic or other comorbidities excluding maximal exercise participation.
• Pregnancy