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In scorpion stings, patients mostly apply with the complaint of pain. Emergency physicians need to relieve this pain quickly.
Aim: In this study, the analgesic efficacy of intravenous (IV) paracetamol, IV dexketoprofen trometamol and topical lidocaine will be compared in patients presenting with pain after scorpion sting.
Methods: This study is a double-blind, randomized, placebo-controlled study conducted in a tertiary emergency department. Adult patients who applied to the study with no systemic findings after scorpion sting and especially with pain will be randomly assigned to one of 4 groups: IV paracetamol, IV dexketoprofen trometamol, topical lidocaine or placebo. In order to determine the intensity of pain, Visual Analog Pain Score (VAS) will be measured at the time of admission to the emergency department, at the 30th minute and at the 60th minute. Afterwards, the VAS score changes between the groups will be compared.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| paracetamol | Active Comparator | 1000 mg intravenous paracetamol |
|
| Dexketoprofen Trometamol | Experimental | 50 mg intravenous Dexketoprofen Trometamol |
|
| topical lidocaine | Experimental | %5 lidocaine 5 gr topical |
|
| placebo | Placebo Comparator | 100 mL intravenous normal saline+ placebo topical pomade |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| paracetamol | Drug | 1000 mg intravenous paracetamol in 100 mL normal saline |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of the intensity of pain | Pain intense will be measured by 100 mm visual analog scale (Zero; no pain and 100 mm; the worst pain) after 30th and 60th minutes later after the study drug administered | 30 minutes and 60 minutes after the study drug administered |
| Measure | Description | Time Frame |
|---|---|---|
| Adverse events | 60 minutes after the study drug administered | 60 minutes after the study drug administered |
| need to rescue medication | 60 minutes after the study drug administered |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Umut Gülaçtı | Adiyaman University of Medical Faculty | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Adiyaman University Research Hospital | Adıyaman | Central | 02000 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D065008 | Scorpion Stings |
| ID | Term |
|---|---|
| D001733 | Bites and Stings |
| D011041 | Poisoning |
| D064419 | Chemically-Induced Disorders |
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D000082 | Acetaminophen |
| C118296 | dexketoprofen trometamol |
| D008012 | Lidocaine |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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| Dexketoprofen Trometamol | Drug | 50 mg intravenous dexketoprofen Trometamol in 100 mL normal saline |
|
|
| Lidocaine topical | Drug | Application of 5 gr of 5% topical lidocaine |
|
|
| Placebo | Drug | 100 mL intravenous normal saline infusion+ placebo topical pomade application |
|
|
| 60 minutes after the study drug administered |
| Aniline Compounds |
| D000588 | Amines |