Dietary Inorganic Nitrate and the Enteral Microbiome

Influence of Exogenous Dietary Inorganic Nitrate on Downstream Metabolites of the Enteral Microbiome

A growing body of data shows that the enteral microbiome has an effect on cardiovascular diseases. Exogenous inorganic dietary nitrate mediates cardioprotective effects and has been shown to have an influence on the oral microbiome. The nutritional aspects of these cardioprotective effects are particularly intriguing since nitrate is abundant in our everyday diet.

Whether dietary nitrate influences the enteral microbiome and downstream metabolites like short-chain fatty acids (SCFA) and TMAO will be investigated in the present study.

Inclusion Criteria:

• Patients aged 40-80 years
• no regular medication intake
• no chronic diseases

Exclusion Criteria:

• Regular systemic drug intake
• Active smoking
• Chronic diseases
• Acute diarrhea or vomiting
• Short gut syndrome
• Pregnancy or breastfeeding